Phenotypes associated with this allele

• Allele Symbol: Tie1^tm1Jpa
• Allele Name: targeted mutation 1, Juha Partanen
• Allele ID: MGI:2159370
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851522
hm2	Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4454554
cx3	Tek^tm1Dmt/Tek^tm1Dmt Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851553
cx4	Tek^tm1Dmt/Tek^+ Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851554

Genotype
MGI:3851522

hm1

• Allelic Composition: Tie1^tm1Jpa/Tie1^tm1Jpa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:30121 )

• mice die by E14.5

cardiovascular system

hemorrhage ( J:30121 )

• at E13.5, small vascular hemorrhages throughout the body are observed unlike in wild-type mice

• by E14.5, hemorrhaging is extreme

homeostasis/metabolism

edema ( J:30121 )

• abdominal edema by E14.5

Genotype
MGI:4454554

hm2

• Allelic Composition: Tie1^tm1Jpa/Tie1^tm1Jpa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

cardiovascular system

cardiovascular system phenotype ( J:159507 )

N • at E12.5, mice exhibit normal blood vessel patterning and integrity

hemorrhage ( J:159507 )

• at E13

homeostasis/metabolism

edema ( J:159507 )

• at E12.5, mice exhibit swelling in the dorsal and neck region unlike in wild-type mice

• at E13, mice exhibit swelling unlike wild-type mice

immune system

abnormal lymphangiogenesis ( J:159507 )

• at E12.5, E13.5, and E14.5, mice exhibit abnormally patterned lymph sacs compared with wild-type mice as determined by marker expression

Genotype
MGI:3851553

cx3

• Allelic Composition: Tek^tm1Dmt/Tek^tm1Dmt; Tie1^tm1Jpa/Tie1^tm1Jpa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54983 )

• mice die by E10.5

cardiovascular system

abnormal blood vessel morphology ( J:54983 )

• blood vessels in the dorsal, posterior portion of the mouse are enlarged and highly distorted compared to in wild-type mice

abnormal vascular development ( J:54983 )

• blood vessel development fails to proceed to the dorsal portion of the body unlike in wild-type mice

• vessel integrity is compromised compared to in wild-type mice

decreased angiogenesis ( J:54983 )

• mice exhibit poor branching structures of the blood vessels in the head unlike wild-type mice

absent organized vascular network ( J:54983 )

• blood vessels fail to organize into large and small vessels unlike in wild-type mice

abnormal vitelline vasculature morphology ( J:54983 )

• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice

abnormal myocardial trabeculae morphology ( J:54983 )

• myocardial trabeculation in the ventricle is absent

abnormal heart development ( J:54983 )

• at E9.5, heart development is poor

• mice exhibit reduced endocardial tissue in the common atrial and ventricular chambers compared to in wild-type mice

• mice exhibit thin myocardial layer, poor maintenance of endocardial contact, and absence of trabeculations unlike in wild-type mice

enlarged pericardium ( J:54983 )

congestive heart failure ( J:54983 )

embryo

abnormal vitelline vasculature morphology ( J:54983 )

• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice

decreased embryo size ( J:54983 )

• at E9.5

abnormal somite development ( J:54983 )

• somites are disorganized and necrotic unlike in wild-type mice

embryo tissue necrosis ( J:54983 )

• at E9.5, necrotic tissue is occasionally observed

• at E10.5, necrosis is widespread

abnormal vitelline vascular remodeling ( J:54983 )

• remodeling of primary yolk sac capillary plexus fails

homeostasis/metabolism

edema ( J:54983 )

• at E9.5

growth/size/body

decreased embryo size ( J:54983 )

• at E9.5

muscle

abnormal myocardial trabeculae morphology ( J:54983 )

• myocardial trabeculation in the ventricle is absent

nervous system

abnormal forebrain development ( J:54983 )

• underdeveloped at E9.5

Genotype
MGI:3851554

cx4

• Allelic Composition: Tek^tm1Dmt/Tek⁺; Tie1^tm1Jpa/Tie1^tm1Jpa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54983 )

• mice die by E10.5

cardiovascular system

abnormal cardiovascular development ( J:54983 )

• at E9.5

abnormal vascular development ( J:54983 )

• maintenance of blood vessels in the head and extremities is poor

abnormal heart development ( J:54983 )

• atrial and ventricular endocardium is poorly maintained

enlarged pericardium ( J:54983 )

hemorrhage ( J:54983 )

heart hemorrhage ( J:54983 )

congestive heart failure ( J:54983 )

homeostasis/metabolism

edema ( J:54983 )