All Phenotypes Tie1<tm1Jpa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851522
hm2	Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4454554
cx3	Tek^tm1Dmt/Tek^tm1Dmt Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851553
cx4	Tek^tm1Dmt/Tek⁺ Tie1^tm1Jpa/Tie1^tm1Jpa	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851554

Allelic Composition	Tie1^tm1Jpa/Tie1^tm1Jpa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tie1^tm1Jpa mutation (2 available); any Tie1 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:30121 )

• mice die by E14.5

cardiovascular system

hemorrhage ( J:30121 )

• at E13.5, small vascular hemorrhages throughout the body are observed unlike in wild-type mice

• by E14.5, hemorrhaging is extreme

homeostasis/metabolism

edema ( J:30121 )

• abdominal edema by E14.5

Allelic Composition	Tie1^tm1Jpa/Tie1^tm1Jpa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tie1^tm1Jpa mutation (2 available); any Tie1 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:159507 )

N	• at E12.5, mice exhibit normal blood vessel patterning and integrity

hemorrhage ( J:159507 )

• at E13

homeostasis/metabolism

edema ( J:159507 )

• at E12.5, mice exhibit swelling in the dorsal and neck region unlike in wild-type mice

• at E13, mice exhibit swelling unlike wild-type mice

immune system

abnormal lymphangiogenesis ( J:159507 )

• at E12.5, E13.5, and E14.5, mice exhibit abnormally patterned lymph sacs compared with wild-type mice as determined by marker expression

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54983 )

• mice die by E10.5

cardiovascular system

abnormal blood vessel morphology ( J:54983 )

• blood vessels in the dorsal, posterior portion of the mouse are enlarged and highly distorted compared to in wild-type mice

abnormal vascular development ( J:54983 )

• blood vessel development fails to proceed to the dorsal portion of the body unlike in wild-type mice

• vessel integrity is compromised compared to in wild-type mice

decreased angiogenesis ( J:54983 )

• mice exhibit poor branching structures of the blood vessels in the head unlike wild-type mice

absent organized vascular network ( J:54983 )

• blood vessels fail to organize into large and small vessels unlike in wild-type mice

abnormal vitelline vasculature morphology ( J:54983 )

• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice

abnormal myocardial trabeculae morphology ( J:54983 )

• myocardial trabeculation in the ventricle is absent

abnormal heart development ( J:54983 )

• at E9.5, heart development is poor

• mice exhibit reduced endocardial tissue in the common atrial and ventricular chambers compared to in wild-type mice

• mice exhibit thin myocardial layer, poor maintenance of endocardial contact, and absence of trabeculations unlike in wild-type mice

enlarged pericardium ( J:54983 )

congestive heart failure ( J:54983 )

embryo

abnormal vitelline vasculature morphology ( J:54983 )

• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice

embryo tissue necrosis ( J:54983 )

• at E9.5, necrotic tissue is occasionally observed

• at E10.5, necrosis is widespread

decreased embryo size ( J:54983 )

• at E9.5

abnormal somite development ( J:54983 )

• somites are disorganized and necrotic unlike in wild-type mice

abnormal vitelline vascular remodeling ( J:54983 )

• remodeling of primary yolk sac capillary plexus fails

homeostasis/metabolism

edema ( J:54983 )

• at E9.5

growth/size/body

decreased embryo size ( J:54983 )

• at E9.5

muscle

abnormal myocardial trabeculae morphology ( J:54983 )

• myocardial trabeculation in the ventricle is absent

nervous system

abnormal forebrain development ( J:54983 )

• underdeveloped at E9.5

cellular

embryo tissue necrosis ( J:54983 )

• at E9.5, necrotic tissue is occasionally observed

• at E10.5, necrosis is widespread

Allelic Composition	Tek^tm1Dmt/Tek⁺ Tie1^tm1Jpa/Tie1^tm1Jpa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tek^tm1Dmt mutation (1 available); any Tek mutation (92 available)
Tie1^tm1Jpa mutation (2 available); any Tie1 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54983 )

• mice die by E10.5

cardiovascular system

abnormal cardiovascular development ( J:54983 )

• at E9.5

abnormal vascular development ( J:54983 )

• maintenance of blood vessels in the head and extremities is poor

abnormal heart development ( J:54983 )

• atrial and ventricular endocardium is poorly maintained

enlarged pericardium ( J:54983 )

hemorrhage ( J:54983 )

heart hemorrhage ( J:54983 )

congestive heart failure ( J:54983 )

homeostasis/metabolism

edema ( J:54983 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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