All Phenotypes Neurog2<tm2Fgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Neurog2^tm2Fgu
targeted mutation 2, Francois Guillemot
MGI:2159010

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurog2^tm2Fgu/Neurog2^tm2Fgu	involves: 129S1/Sv * 129X1/SvJ	MGI:3703638
hm2	Neurog2^tm2Fgu/Neurog2^tm2Fgu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1	MGI:3623000
cx3	Ascl1^tm1And/Ascl1^tm1And Neurog2^tm2Fgu/Neurog2^tm2Fgu	involves: 129 * C57BL/6J * CD-1b	MGI:3622999
cx4	Neurog1^tm1And/Neurog1^tm1And Neurog2^tm2Fgu/Neurog2^tm2Fgu	involves: 129/Sv * C57BL/6J * CD-1	MGI:3622997

Allelic Composition	Neurog2^tm2Fgu/Neurog2^tm2Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2^tm2Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:109091 )

• fraction of cells in cortex expressing HuC/D, a differentiation marker, is reduced in cultures after 4 days than in controls electroporated with a GFP vector

decreased Cajal-Retzius cell number ( J:139170 )

• the numbers of Cajal-Retzius cells derived from the dorsal telencephalic midline is decreased compared to in wild-type mice

• however, the number of Cajal-Retzius cells in the piriform cortex is normal

cellular

abnormal neuron differentiation ( J:109091 )

• fraction of cells in cortex expressing HuC/D, a differentiation marker, is reduced in cultures after 4 days than in controls electroporated with a GFP vector

Allelic Composition	Neurog2^tm2Fgu/Neurog2^tm2Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2^tm2Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:59428 )

• mice exhibit perinatal lethality identical to Neurog2^tm1Fgu animals

nervous system

abnormal forebrain morphology ( J:59428 )

• in the mutant cortex, there are ventral-type neurons instead of only dorsal-type

abnormal thalamus morphology ( J:59428 )

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons

Allelic Composition	Ascl1^tm1And/Ascl1^tm1And Neurog2^tm2Fgu/Neurog2^tm2Fgu
Genetic Background	involves: 129 * C57BL/6J * CD-1b

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl1^tm1And mutation (1 available); any Ascl1 mutation (27 available)
Neurog2^tm2Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:59428 )

• there is a reduced number ectopic ventral-type neurons with a lateral rather than dorsal location compared to Neurog2 nulls

Allelic Composition	Neurog1^tm1And/Neurog1^tm1And Neurog2^tm2Fgu/Neurog2^tm2Fgu
Genetic Background	involves: 129/Sv * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog1^tm1And mutation (1 available); any Neurog1 mutation (19 available)
Neurog2^tm2Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:59428 )

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons; a population of ventral neurons in the dorsal tetncephalon are of dorsal origin

abnormal thalamus morphology ( J:59428 )

• the dorsal thalamus of double mutants is abnormal with an enlargement of the ventricular zone and a reduction in the size of the mantle zone

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons

• at E12.5, there is an increase in the number of cells expressing a pan-neuronal marker compared to wild-type

cellular

abnormal neuron differentiation ( J:59428 )

• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons; a population of ventral neurons in the dorsal tetncephalon are of dorsal origin

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