Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2tm2Fgu mutation
(0 available);
any
Neurog2 mutation
(18 available)
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nervous system
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• fraction of cells in cortex expressing HuC/D, a differentiation marker, is reduced in cultures after 4 days than in controls electroporated with a GFP vector
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• the numbers of Cajal-Retzius cells derived from the dorsal telencephalic midline is decreased compared to in wild-type mice
• however, the number of Cajal-Retzius cells in the piriform cortex is normal
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cellular
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• fraction of cells in cortex expressing HuC/D, a differentiation marker, is reduced in cultures after 4 days than in controls electroporated with a GFP vector
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2tm2Fgu mutation
(0 available);
any
Neurog2 mutation
(18 available)
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mortality/aging
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• mice exhibit perinatal lethality identical to Neurog2tm1Fgu animals
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nervous system
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• in the mutant cortex, there are ventral-type neurons instead of only dorsal-type
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• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl1tm1And mutation
(1 available);
any
Ascl1 mutation
(28 available)
Neurog2tm2Fgu mutation
(0 available);
any
Neurog2 mutation
(18 available)
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nervous system
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• there is a reduced number ectopic ventral-type neurons with a lateral rather than dorsal location compared to Neurog2 nulls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog1tm1And mutation
(1 available);
any
Neurog1 mutation
(19 available)
Neurog2tm2Fgu mutation
(0 available);
any
Neurog2 mutation
(18 available)
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nervous system
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• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons; a population of ventral neurons in the dorsal tetncephalon are of dorsal origin
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• the dorsal thalamus of double mutants is abnormal with an enlargement of the ventricular zone and a reduction in the size of the mantle zone
• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons
• at E12.5, there is an increase in the number of cells expressing a pan-neuronal marker compared to wild-type
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cellular
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• neuronal patterning is abnomal in the thalamus, indicating misspecification of neurons; a population of ventral neurons in the dorsal tetncephalon are of dorsal origin
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