Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc1tm1Dwm mutation
(0 available);
any
Ercc1 mutation
(27 available)
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mortality/aging
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• died before weaning of liver failure
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liver/biliary system
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• evidenced by a 15-fold increase in alanine aminotransferase activity
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• evidenced by a 2-fold increase in alkaline phosphatase levels and 7-fold increase in bilirubin
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cellular
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• liver cells showed variation in nuclear size
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• severe aneuploidy seen in liver cells by 3 weeks of age
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• perinatal liver cells showed varying degrees of polyploidy
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growth/size/body
Allelic
Composition |
Ercc1tm1Dwm/Ercc1+
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Genetic
Background |
involves: 129P2/OlaHsd * BALB/c |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc1tm1Dwm mutation
(0 available);
any
Ercc1 mutation
(27 available)
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liver/biliary system
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• an increase in alanine aminotransferase activity approaching values for homozygotes suggested liver cell injury occurs before detectable in histological preparations
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc1tm1Dwm mutation
(0 available);
any
Ercc1 mutation
(27 available)
Ercc1tm2Dwm mutation
(0 available);
any
Ercc1 mutation
(27 available)
Hrhr mutation
(17 available);
any
Hr mutation
(84 available)
Tg(KRT5-cre)5132Jlj mutation
(1 available)
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mortality/aging
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• mice with a maternally inherited cre transgene die before weaning
• however, mice with a paternally inherited cre transgene are viable
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neoplasm
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• mice with a paternally inherited cre transgene develop tumors following chronic exposure to 125 J/m2 UVB unlike control mice
• tumors appear earlier and grow faster in mice with a paternally inherited cre transgene compared to control mice receiving a 16-fold higher dose of UVB
• the cumulative UVB EC50 for tumor development is 3.75 kJ/m2 in mice with a paternally inherited cre transgene compared to 140 kJ/m2control mice
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growth/size/body
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• mice with a maternally inherited cre transgene are severely runted at birth
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liver/biliary system
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• mice with a maternally inherited cre transgene develop premature polyploidy in hepatocytes
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integument
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• the minimal erythemal dose of UVB is 40 J/m2 in mice with a paternally inherited cre transgene compared to 900 J/m2 in controls
• in mice with a paternally inherited cre transgene sensitivity to UVB induced changes in the epidermis (hyperplasia, hypertrophy, hypergranulosis, and hyperkeratosis) are increased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc1tm1Dwm mutation
(0 available);
any
Ercc1 mutation
(27 available)
Tg(Ttr-Ercc1)17Dwm mutation
(0 available)
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mortality/aging
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• mice survived nolonger than 88 days
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reproductive system
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• spermatagonial cell death is abnormally high in 7 week old mice
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• no primary follicles are found in the periphery of the ovary
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• majority of oocytes appeared to be degenerating
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• significantly fewer germs cells in both males and females
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cellular
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• significantly fewer germs cells in both males and females
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• polyploid nuclei found in cells of kidney proximal tubules
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• process of polyploidy is similar to the premature liver polyploidy of mice homozygous for Ercc1tm1Dwm
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• spermatagonial cell death is abnormally high in 7 week old mice
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endocrine/exocrine glands
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• no primary follicles are found in the periphery of the ovary
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• majority of oocytes appeared to be degenerating
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renal/urinary system
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• mice died between 61 and 88 days
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homeostasis/metabolism
Analysis Tools