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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptprdtm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:2158795
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptprdtm1Yiw/Ptprdtm1Yiw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3056784
cx2
 		Ptprdtm1Yiw/Ptprdtm1Yiw
Ptprstm1Mtr/Ptprstm1Mtr 		B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr MGI:4839393
cx3
 		Ptprdtm1Yiw/Ptprdtm1Yiw
Ptprstm1Mtr/Ptprs+ 		B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr MGI:4839394
cx4
 		Ptprdtm1Yiw/Ptprd+
Ptprstm1Mtr/Ptprstm1Mtr 		B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr MGI:4839395


Genotype
MGI:3056784
hm1
Allelic
Composition		 Ptprdtm1Yiw/Ptprdtm1Yiw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:63046 )
• 60% die by 35 days, unless food relocated to floor of cage

behavior/neurological
abnormal spatial learning ( J:63046 )
• impaired ability to find platform in Morris water maze
• impaired ability in reinforced alternation task (T maze)
• impaired ability in radial arm maze
abnormal eating behavior ( J:63046 )
• difficulty in obtaining food from elevated position
impaired swimming ( J:63046 )
• body rolls while swimming

growth/size/body
decreased body weight ( J:63046 )

nervous system
enhanced long-term potentiation ( J:63046 )
• in CA3 and CA1 pyramidal neurons following tetanic stimulation
enhanced paired-pulse facilitation ( J:63046 )
• in hippocampal CA1 synapses
• threshold of the pulse interval causing facilitation is prolonged




Genotype
MGI:4839393
cx2
Allelic
Composition		 Ptprdtm1Yiw/Ptprdtm1Yiw
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background		 B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (120 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:109122 )
• mutants are viable to late embryogenesis E18.5, born but never breathe

skeleton
axial skeleton hypoplasia ( J:109122 )
• E18.5 skeletal muscle fibers are smaller in diameter, with their nuclei centrally localized along the fiber

behavior/neurological

respiratory system
abnormal pulmonary alveolus morphology ( J:109122 )
• alveoli of E18.5 are tightly compressed

adipose tissue
increased subcutaneous adipose tissue amount ( J:109122 )
• subcutaneous tissues are enlarged
abnormal brown adipose tissue morphology ( J:109122 )
• the compartmentalization of brown adipose tissue is less obvious

muscle
centrally nucleated skeletal muscle fibers ( J:109122 )
• in E18.5 skeletal muscle fibers
thin diaphragm muscle ( J:109122 )
• at E16.5 the mean thickness of the diaphragm is thinner
hypaxial muscle hypoplasia ( J:109122 )
• a reduction in the mass of dorsal axial skeletal muscles and limb muscles

nervous system
abnormal motor neuron morphology ( J:109122 )
• only a few morphologically abnormal motoneurons that exhibit a smaller cytoplasm with Nissl bodies and an indistinct nucleolus, are found
decreased motor neuron number ( J:109122 )
• a decrease occurs late in embryogenesis between E13 and E18.5, during motoneuron axon extension
abnormal phrenic nerve morphology ( J:109122 )
• at E13.5 although the phrenic nerve appears to reach the appropriate initial location on the diaphragm, the two main sternocostal branches that normally defasciculate from the main nerve are retracted
• at 15.5 and E18.5 complete absence of sternocostal branches

integument
increased subcutaneous adipose tissue amount ( J:109122 )
• subcutaneous tissues are enlarged
underdeveloped hair follicles ( J:109122 )
• hair follicles are not fully developed at E18.5
translucent skin ( J:109122 )
• from E15




Genotype
MGI:4839394
cx3
Allelic
Composition		 Ptprdtm1Yiw/Ptprdtm1Yiw
Ptprstm1Mtr/Ptprs+
Genetic
Background		 B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (120 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal phrenic nerve morphology ( J:109122 )
• capillaceous nerves are seldom observed to defasciculate from the major sternocostal branches




Genotype
MGI:4839395
cx4
Allelic
Composition		 Ptprdtm1Yiw/Ptprd+
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background		 B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (120 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased motor neuron number ( J:109122 )
• a modest reduction of the number of motoneurons
abnormal phrenic nerve morphology ( J:109122 )
• capillaceous nerves are seldom observed to defasciculate from the major sternocostal branches




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory