All Phenotypes Gli2<tm3.1(Gli1)Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli2^{tm3.1(Gli1)Alj}
targeted mutation 3.1, Alexandra L Joyner
MGI:2158720

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli2^{tm3.1(Gli1)Alj}/Gli2^{tm3.1(Gli1)Alj}	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846349
ht2	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846353
ht3	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj}	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846347
cx4	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj} Shh^tm1Chg/Shh^tm1Chg	either: (involves: 129) or (involves: 129 * Black Swiss)	MGI:3846352
cx5	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺ Gli3^Xt-J/Gli3⁺	either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)	MGI:3846354
cx6	Gli1^tm2Alj/Gli1^tm2Alj Gli2^{tm3.1(Gli1)Alj}/Gli2^{tm3.1(Gli1)Alj}	involves: 129/Sv * Black Swiss * Swiss Webster	MGI:3795859

Allelic Composition	Gli2^{tm3.1(Gli1)Alj}/Gli2^{tm3.1(Gli1)Alj}
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:73074 )

• no mice are found at weaning

nervous system

nervous system phenotype ( J:73074 )

N	• unlike in homozygous null mice, differentiation of floor plate, ventral interneurons and motor neurons is normal

Allelic Composition	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

progressive hair loss ( J:73074 )

• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age

• around 5 months of age mice lack hair around the neck

Allelic Composition	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj}
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:73074 )

N	• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal

respiratory system

respiratory system phenotype ( J:73074 )

N	• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present

integument

progressive hair loss ( J:73074 )

• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age

• around 5 months of age mice lack hair around the neck

Allelic Composition	Gli2^tm2.1Alj/Gli2^{tm3.1(Gli1)Alj} Shh^tm1Chg/Shh^tm1Chg
Genetic Background	either: (involves: 129) or (involves: 129 * Black Swiss)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:73074 )

• at E10.5

abnormal diencephalon morphology ( J:73074 )

• in about half of mice development of the diencephalic vesicles is partially rescued with partial separation into 2 vesicles seen at E10.5 or E11.5

decreased motor neuron number ( J:73074 )

• absent from the spinal cord at E10.5

abnormal ventral interneuron 3 morphology ( J:73074 )

• absence of V3 interneurons at E10.5

embryo

absent floor plate ( J:73074 )

• at E10.5

growth/size/body

megacephaly ( J:73074 )

• head size is increased compared to mice homozygous null for Shh alone

Allelic Composition	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺ Gli3^Xt-J/Gli3⁺
Genetic Background	either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:73074 )

• females die by 6 weeks of age

limbs/digits/tail

polydactyly ( J:73074 )

• polydactyl is enhanced compared to mice heterozygous for Gli3^Xt-J alone

reproductive system

male infertility ( J:73074 )

• all males are sterile

integument

progressive hair loss ( J:73074 )

• hair loss is more severe compared to mice heterozygous for Gli2^{tm3.1(Gli2)Alj} alone

Allelic Composition	Gli1^tm2Alj/Gli1^tm2Alj Gli2^{tm3.1(Gli1)Alj}/Gli2^{tm3.1(Gli1)Alj}
Genetic Background	involves: 129/Sv * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm2Alj mutation (1 available); any Gli1 mutation (48 available)
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:79392 )

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