Phenotypes associated with this allele

• Allele Symbol: Cfb^tm1Mbo
• Allele Name: targeted mutation 1, Marina Botto
• Allele ID: MGI:2158706
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfb^tm1Mbo/Cfb^tm1Mbo	involves: 129/Sv * C57BL/6	MGI:2664972

Genotype
MGI:2664972

hm1

• Allelic Composition: Cfb^tm1Mbo/Cfb^tm1Mbo
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:83712 )

• animals challenged with virulent pneumococci develop bacteremia and pneumonia after passive immunization with human IgG1 or human IgG2 unlike wild-type mice that are protected after immunization

• mutants passively immunized with human IgG1 antibodies and challenged with virulent pneumococci show reduced number of pneumococcal CFU in spleens even though they are not protected by the immunization