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Cfbtm1Mbo
Targeted Allele Detail
Summary
Symbol: Cfbtm1Mbo
Name: complement factor B; targeted mutation 1, Marina Botto
MGI ID: MGI:2158706
Synonyms: B/C2-, Bf/C2-, C2/FB-, C2/fB KO
Gene: Cfb  Location: Chr17:35075350-35081492 bp, - strand  Genetic Position: Chr17, 18.41 cM
Alliance: Cfbtm1Mbo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45297
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 6 kb genomic fragment containing part of exon 1 through exon 18 was replaced with a promoterless lacZ gene linked to a neomycin selection cassette. Northern blot analysis on liver RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Activity assays on serum derived from homozygous mice confirmed that no functional protein was made. (J:45297)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfb Mutation:  29 strains or lines available
References
Original:  J:45297 Taylor PR, et al., A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45. J Biol Chem. 1998 Jan 16;273(3):1699-704
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory