Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
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mortality/aging
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• at E6.5-E8.5, homozygotes are recovered at the expected Mendelian frequency but appear abnormal
• no homozygotes are recovered at E9.5
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embryo
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• homozygotes fail to undergo normal gastrulation
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• at E7.5, homozygotes lack a properly established A-P axis
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• homozygotes are arrested at the egg cylinder stage before gastrulation
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• at E6.5, homozygotes exhibit progressive growth retardation and are significantly smaller than wild-type embryos
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• at E6.5 and E7.5, homozygotes display impaired epiblast differentiation; in contrast, expression of tissue-specific genes for visceral endoderm differentiation is relatively normal
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• at E6.5, homozygotes fail to form elongated egg cylinders
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• at E7.5, homozygous mutant embryos lack a mesoderm layer
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• at E7.5, homozygotes lack a morphologically identifiable primitive streak
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• at E6.5, homozygous mutant embryos are disorganized and lack a clear distinction between the embryonic and extraembryonic portions
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growth/size/body
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• at E6.5, homozygotes exhibit progressive growth retardation and are significantly smaller than wild-type embryos
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Allelic Composition |
Bmpr2tm1Kmi/Bmpr2+
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Genetic Background |
involves: 129S4/SvJae |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
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skeleton
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• eight ribs, instead of nine, were attached to the sternum
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• exhibited alleviated vertebral defects compared to homozygous Acvr2b mutants
• transformation of the 23rd vertebra to the 16th thoracic vertebra (as seen in homozygous Acvr2b mutants) was incomplete
• vertebra 29 of most mutants was transformed to the first sacral vertebra instead to the 6th lumbar vertebra (as seen in homozygous Acvr2b mutants)
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Allelic Composition |
Bmpr2tm1Kmi/Bmpr2+
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
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cardiovascular system
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• heterozygotes exhibit an increase in wall thickness of muscularized pulmonary arteries
• heterozygotes exposed to hypoxia exhibit impaired muscularization of small pulmonary arteries in both the distal intra-acinar vessels and in proximal preacinar vessels, with 25% less increase in wall thickness compared to controls
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• the number of alveoli (and associated capillaries called alveolar-capillary units) per millimeter squared is 40% greater in heterozygotes
• heterozygotes exposed to prolonged hypoxia exhibit impaired pulmonary vascular remodeling, with a smaller increase in pulmonary artery pressure, greater right ventricular hypertrophy, decrease in the number of alveolar-capillary units per millimeter squared, and decreased wall thickness (muscularization) of small pulmonary arteries compared to controls
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• increase in mean total pulmonary vascular resistance and in incremental pulmonary resistance
• however total systemic vascular resistance is not different
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• increase in mean pulmonary arterial pressure
• however, mean systemic arterial pressure is not different from controls
• heterozygotes exposed to prolonged hypoxia show a smaller increase in pulmonary artery pressure than control mice
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• mutants develop mild pulmonary hypertension
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respiratory system
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• the number of alveoli (and associated capillaries called alveolar-capillary units) per millimeter squared is 40% greater in heterozygotes
• heterozygotes exposed to prolonged hypoxia exhibit impaired pulmonary vascular remodeling, with a smaller increase in pulmonary artery pressure, greater right ventricular hypertrophy, decrease in the number of alveolar-capillary units per millimeter squared, and decreased wall thickness (muscularization) of small pulmonary arteries compared to controls
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• the number of alveoli (and associated capillaries called alveolar-capillary units) per millimeter squared is 40% greater in heterozygotes, decreasing the vessels-to-alveoli ratio
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Allelic Composition |
Bmpr2tm1Kmi/Bmpr2+
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Genetic Background |
involves: 129S4/SvJae * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
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cardiovascular system
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• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice
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• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit increased right ventricular systolic pressure compared to wild-type mice with the same treatment, indicating increased sensitivity to stress-induced pulmonary hypertension
• however, mutants exhibit normal right ventricular systolic pressure and do not develop pulmonary hypertension spontaneously under unstressed conditions
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• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction
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immune system
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• minor increase in adhesion of leukocytes to the vessel wall in the lungs
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mortality/aging
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• about 20% fewer than the expected number of heterozygous mice were detected, indicating loss in early development
• most mice that do not survive, die in utero, although some die in the immediate postnatal stage
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muscle
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• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction
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respiratory system
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• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice
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hematopoietic system
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• minor increase in adhesion of leukocytes to the vessel wall in the lungs
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1.1Enl mutation
(1 available);
any
Bmpr2 mutation
(45 available)
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
Tg(KRT14-cre)1Ipc mutation
(0 available)
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normal phenotype
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• mice are healthy, fertile, and overtly normal with no apparent skin defects
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
Btg2tm1Spo mutation
(0 available);
any
Btg2 mutation
(14 available)
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skeleton
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• mutants exhibited similar vertebral abnormalities as single homozygous Btg2 mutants, with no differences in the severity of phenotype
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2cGt(P9-3F)Sor mutation
(0 available);
any
Ark2c mutation
(11 available)
Bmpr2tm1Kmi mutation
(0 available);
any
Bmpr2 mutation
(45 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• fewer than expected mice are born
• however, all born mice survive to adulthood
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nervous system
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• some mice exhibit innervation defects in the dorsal forelimb
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behavior/neurological
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• some mice exhibit reduced hang time from a cage lid compared with wild-type mice
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