Phenotypes associated with this allele
Allelic
Composition |
Gli2tm2.1Alj/Gli2tm2.1Alj
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Genetic
Background |
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
|
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nervous system
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• at E10.5 cells that express Shh and Foxa2 are absent
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• at E10.5 motor neurons occupy the ventral midline of the spinal cord
• the notochord is situated closer to the spinal cord
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• decrease in the number of spinal cord V3 interneurons that are normally adjacent to the floor plate at E10.5
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embryo
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• at E10.5 cells that express Shh and Foxa2 are absent
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• at E10.5 cells that express Shh and Foxa2 are absent
• the notochord is situated closer to the spinal cord
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• the notochord fails to regress
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respiratory system
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• the accessory lobe is absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
|
|
|
mortality/aging
reproductive system
|
N |
• embryos show normal mammary gland development at E13
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
|
|
|
embryo
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• the Nkx2-2 expressing domains are absent and the motor neurons appear fused together
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nervous system
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• the Nkx2-2 expressing domains are absent and the motor neurons appear fused together
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• in the floor plate the motor neurons appear fused together
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Allelic
Composition |
Gli2tm1Alj/Gli2tm2.1Alj
|
|
Genetic
Background |
either: (involves: 129) or (involves: 129 * Black Swiss) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm1Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
|
|
|
nervous system
|
|
• at E10.5 cells that express Shh and Foxa2 are absent
|
|
|
• at E10.5 motor neurons occupy the ventral midline of the spinal cord
• the notochord is situated closer to the spinal cord
|
|
|
• decrease in the number of spinal cord V3 interneurons that are normally adjacent to the floor plate at E10.5
|
embryo
|
|
• at E10.5 cells that express Shh and Foxa2 are absent
|
|
|
• at E10.5 cells that express Shh and Foxa2 are absent
• the notochord is situated closer to the spinal cord
|
|
|
• the notochord fails to regress
|
respiratory system
|
|
• the accessory lobe is absent
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
Gli2tm3.1(Gli1)Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
|
|
|
nervous system
|
N |
• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal
|
respiratory system
|
N |
• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present
|
integument
|
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• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age
• around 5 months of age mice lack hair around the neck
|
Allelic
Composition |
Gli2tm2.1Alj/Gli2tm3(Gli1)Alj
|
|
Genetic
Background |
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
Gli2tm3(Gli1)Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
|
|
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normal phenotype
|
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• viable with no gross abnormalities
• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal
• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present
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nervous system
|
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• absent from the spinal cord at E10.5
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vision/eye
embryo
embryo
nervous system
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• fused telencephalic vesicles are seen at E10.5
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• loss of many ventral tissues is seen at E10.5
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growth/size/body
nervous system
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• in about half of mice development of the diencephalic vesicles is partially rescued with partial separation into 2 vesicles seen at E10.5 or E11.5
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• absent from the spinal cord at E10.5
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• absence of V3 interneurons at E10.5
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embryo
growth/size/body
|
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• head size is increased compared to mice homozygous null for Shh alone
|
reproductive system
|
N |
• embryos show normal mammary gland development
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mortality/aging
|
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• embryos die around E10.5
|
Allelic
Composition |
Gli2tm2.1Alj/Gli2+
Gli3Xt-J/Gli3Xt-J
|
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Genetic
Background |
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster |
|
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endocrine/exocrine glands
 |
• some embryos lack mammary bud pair number 3 and number 5
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integument
|
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• some embryos lack mammary bud pair number 3 and number 5
|
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm2.1Alj mutation
(1 available);
any
Gli2 mutation
(169 available)
Tmem107schlei mutation
(0 available);
any
Tmem107 mutation
(20 available)
|
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embryo
|
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• mice exhibit loss of floor plate cells and V3 interneurons
• however, dorsal expansion of V2 interneuron progenitors observed in Tmem107schlei homozygotes is blocked
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nervous system
|
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• mice exhibit loss of floor plate cells and V3 interneurons
• however, dorsal expansion of V2 interneuron progenitors observed in Tmem107schlei homozygotes is blocked
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Analysis Tools