Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1Htno mutation
(0 available);
any
Bcl6 mutation
(55 available)
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reproductive system
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• reduced amount of epididymal sperm
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• increase in germ cell apoptosis beginning at 8 weeks of age
• apoptotic spermatocytes at metaphase I
• apoptosis putatively due to increased susceptibility to stressors
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• 85% of males were unable to sire offspring when mated with wild-type females
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• an impaired fertilization rate was shown in vitro
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cellular
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• reduced amount of epididymal sperm
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• increase in germ cell apoptosis beginning at 8 weeks of age
• apoptotic spermatocytes at metaphase I
• apoptosis putatively due to increased susceptibility to stressors
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1Htno mutation
(0 available);
any
Bcl6 mutation
(55 available)
|
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mortality/aging
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• mutants become sick 4-6 weeks after birth and most die by 9 weeks after birth
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• number of mutants living longer than 3 weeks is smaller than expected
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growth/size/body
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• observed first around 3 weeks of age
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• mean body weight is less than controls at 3 weeks of age
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cardiovascular system
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• severe degeneration of myofibers is seen at necropsy
• prior to eosinophilic infiltration (at 4 weeks of age), myocytes already show degenerative changes such as irregular size of condensed mitochondria, indicating myoctes are damaged prior to eosinophilic infiltration
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• massive myocarditis with eosinophilic infiltration is seen after 4-6 weeks of age
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immune system
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• massive myocarditis with eosinophilic infiltration is seen after 4-6 weeks of age
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• inflammation with eosinophilic infiltration is seen in the spleen
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• inflammation with eosinophilic infiltration is seen in lungs
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hematopoietic system
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• inflammation with eosinophilic infiltration is seen in the spleen
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muscle
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• severe degeneration of myofibers is seen at necropsy
• prior to eosinophilic infiltration (at 4 weeks of age), myocytes already show degenerative changes such as irregular size of condensed mitochondria, indicating myoctes are damaged prior to eosinophilic infiltration
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respiratory system
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• inflammation with eosinophilic infiltration is seen in lungs
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cellular
Allelic Composition |
Bcl6tm1Htno/Bcl6+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1Htno mutation
(0 available);
any
Bcl6 mutation
(55 available)
|
|
|
cellular
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• increased germ cell apoptosis
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