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Allele Symbol Allele Name Allele ID |
St8sia1tm1Rlp targeted mutation 1, Richard L Proia MGI:2158360 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile, have normal growth, and exhibit no gross behavior abnormalities
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| N |
• mice exhibit normal myelination
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice die by 13 weeks
• 92% of mice die by 36 weeks
• 9 of 10 mice die during the tonic phase of an audiogenic seizure due to respiratory arrest
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• sperm maturation is defective
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| N |
• mice exhibit no neuronal cell loss or demyelination
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• some mice exhibit spontaneous and/or handling-induced seizures unlike wild-type mice
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• beginning as a brief wild-running phase and followed by a clonic-tonic seizure
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• 9 of 10 mice die during the tonic phase of a seizure due to respiratory arrest
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• some mice exhibit spontaneous and/or handling-induced seizures unlike wild-type mice
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• beginning as a brief wild-running phase and followed by a clonic-tonic seizure
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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