All Phenotypes Crygb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crygb⁺
wild type
MGI:2158280

Summary

3 genotypes

Allelic Composition	Crygb^Clapper/Crygb⁺
Genetic Background	C57BL/6J-Crygb^Clapper

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crygb^Clapper mutation (1 available); any Crygb mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cataracts in Crygb^Clapper/Crygb^Clapper and Crygb^Clapper/Crygb⁺ mice

vision/eye

lamellar cataract ( J:100851 )

• develop lamellar cataracts, however to a less degree than seen in homozygotes

• disorganized, irregularly shaped, and smaller fibers are seen in the deeper regions of lenses

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 39 multiple types		DOID:0110236	OMIM:615188	J:100851

Allelic Composition	Crygb^Nop/Crygb⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crygb^Nop mutation (1 available); any Crygb mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

nuclear cataract ( J:7589 )

• nuclear opacity seen as a white spot in the eye

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 39 multiple types		DOID:0110236	OMIM:615188	J:7589

Allelic Composition	Crygb^S11R/Crygb⁺
Genetic Background	A/J-Crygb^S11R

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crygb^S11R mutation (0 available); any Crygb mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:132502 )

• at 220-350 um from lens capsule, lenses display unique ringlike structure which causes abnormal light scattering

abnormal lens fiber morphology ( J:132502 )

• inner fiber cells of lenses show uneven toluidine blue staining with abnormally darkly stained areas at P3

• at P21, peripheral fiber cells are relatively normal, similar to wild-type

nuclear cataract ( J:132502 )

• mice display hazy nuclear cataracts by weaning age

• periphery of lens remains transparent, even in older mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 39 multiple types		DOID:0110236	OMIM:615188	J:132502

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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