Analysis Tools|
Allele Symbol Allele Name Allele ID |
Chek1+ wild type MGI:2158251 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• extensive with patches of reduced angiogenesis
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• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
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• tumors are more complex than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes
• tumors exhibit aneuploidy and chromosomal aberrations
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• in tumors
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• in tumors
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• extensive with patches of reduced angiogenesis
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• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice
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• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
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• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
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• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice
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• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice
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• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
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• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
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• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
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• mice develop fewer tumors than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes
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• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
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• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
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• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1tm2.1Sje Trp53tm1Brn Tg(MMTV-cre)Mam heterozygotes
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• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
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• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
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• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1tm2.1Sje Trp53tm1Brn Tg(MMTV-cre)Mam heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 35% of cells in the mammary glands are proliferating at day 1 of lactation compared to 6.5% in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• despite a slight reduction of melanoblast numbers at E13.5, adult mice exhibit normal coat pigmentation relative to control mice
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• at E13.5, a slight but significant reduction of melanoblast numbers is noted in the head, dorsal, and ventral regions relative to control embryos
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• at E13.5, a slight but significant reduction of melanoblast numbers is noted in the head, dorsal, and ventral regions relative to control embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 2 to 12 months, mammary glands are less dense than in wild-type mice
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• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
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• at 2 to 12 months, mammary glands are less dense than in wild-type mice
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• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene
• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation
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• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene
• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation
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• earlier onset of mammary tumors (168 days versus 219 days of age) than in mice carrying only the transgene
• no differences in gross pathology, histopathology, or growth rates of these tumors compared to those in mice carrying only the transgene and not the Chek1 mutation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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