Phenotypes associated with this allele

• Allele Symbol: Atp1b2^{tm1(Atp1b1)Mtg}
• Allele Name: targeted mutation 1, Dirk Montag
• Allele ID: MGI:2157777
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp1b2^tm1(Atp1b1)Mtg/Atp1b2^tm1(Atp1b1)Mtg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3850852

Genotype
MGI:3850852

hm1

• Allelic Composition: Atp1b2^{tm1(Atp1b1)Mtg}/Atp1b2^{tm1(Atp1b1)Mtg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:50902 )

• significant increase in apoptotic photoreceptor cells at 17 days of age

• apoptotic photoreceptor cells also increased at 4 and 9 months of age

abnormal retina neuronal layer morphology ( J:50902 )

abnormal retina photoreceptor morphology ( J:50902 )

short photoreceptor inner segment ( J:50902 )

• the length of the photoreceptor inner segment is significantly reduced

short photoreceptor outer segment ( J:50902 )

• the length of the photoreceptor outer segment is significantly reduced

retina photoreceptor degeneration ( J:50902 )

• progressive degeneration of photoreceptor cells from 17 days of age through 9 months

thin retina outer nuclear layer ( J:50902 )

• at 4 months

• absent or reduced to no more than a few rows of photoreceptors at 9 months of age

retina outer nuclear layer degeneration ( J:50902 )

nervous system

nervous system phenotype ( J:50902 )

N • overall brain morphology is normal

abnormal retina photoreceptor morphology ( J:50902 )

short photoreceptor inner segment ( J:50902 )

• the length of the photoreceptor inner segment is significantly reduced

short photoreceptor outer segment ( J:50902 )

• the length of the photoreceptor outer segment is significantly reduced

retina photoreceptor degeneration ( J:50902 )

• progressive degeneration of photoreceptor cells from 17 days of age through 9 months

cellular

increased retina apoptosis ( J:50902 )

• significant increase in apoptotic photoreceptor cells at 17 days of age

• apoptotic photoreceptor cells also increased at 4 and 9 months of age