Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
cardiovascular system
|
• at 3 weeks after cuff-induced femoral artery injury, homozygotes exhibit significanlty enhanced neointimal formation, as shown by a 249% increase in mean intimal thickness and a 257% increase in neointima/media ratio, with no significant differences in medial thickness relative to wild-type mice
• in addition, homozygotes exhibit a 110% and 862% increase in the PCNA index of intima and adventitia, respectively
|
growth/size/body
|
• at 12 weeks of age, homozygotes exhibit reduced body weight relative to wild-type littermates (25.20.7 g vs 31.11.1 g, respectively)
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
immune system
|
• there is increased secretion of both IL-17A and IL-17F by both lymph node cells and by cells isolated from synovial fluid
|
|
• almost all mice develop autoimmune arthritis in the joints by 24 weeks of age
|
skeleton
|
• almost all mice develop autoimmune arthritis in the joints by 24 weeks of age
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
growth/size/body
|
• mice exhibit growth retardation after 6-8 weeks of age
• by 12 weeks of age, mean weight for males is 6 grams less than controls and 3 grams less for females
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ftm1Yiw mutation
(0 available);
any
Il17f mutation
(27 available)
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
immune system
|
• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rntm1Yiw allele
|
skeleton
|
• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rntm1Yiw allele
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation
(0 available);
any
Il17a mutation
(22 available)
Il17ftm1Yiw mutation
(0 available);
any
Il17f mutation
(27 available)
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
immune system
|
• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes
|
skeleton
|
• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation
(0 available);
any
Il17a mutation
(22 available)
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation
(0 available);
any
Il17a mutation
(22 available)
Il1rntm1Yiw mutation
(0 available);
any
Il1rn mutation
(23 available)
|
|
|
immune system
|
• reduced incidence of arthritis
• severity of arthritis not reduced
|
skeleton
|
• reduced incidence of arthritis
• severity of arthritis not reduced
|