All Phenotypes Il1b<tm1Yiw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il1b^tm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:2157396

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1b^tm1Yiw/Il1b^tm1Yiw	involves: 129S1/Sv * 129X1/SvJ	MGI:4939417
hm2	Il1b^tm1Yiw/Il1b^tm1Yiw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4360501
cx3	Il1a^tm1Yiw/Il1a^tm1Yiw Il1b^tm1Yiw/Il1b^tm1Yiw	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:4360919
cx4	Il1a^tm1Yiw/Il1a^tm1Yiw Il1b^tm1Yiw/Il1b^tm1Yiw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4360503
cx5	Il1a^tm1Yiw/Il1a^tm1Yiw Il1b^tm1Yiw/Il1b^tm1Yiw Tg(KRT14-CASP1)1Miz/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5563673

Allelic Composition	Il1b^tm1Yiw/Il1b^tm1Yiw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1b^tm1Yiw mutation (0 available); any Il1b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular wound healing ( J:107324 )

• following carotid ligation, mice exhibit a 3-fold reduction in absolute neointima and 4-fold reduction in lumen area compared with wild-type mice

• however, total vessel area is normal after carotid ligation

homeostasis/metabolism

abnormal vascular wound healing ( J:107324 )

• following carotid ligation, mice exhibit a 3-fold reduction in absolute neointima and 4-fold reduction in lumen area compared with wild-type mice

• however, total vessel area is normal after carotid ligation

Allelic Composition	Il1b^tm1Yiw/Il1b^tm1Yiw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1b^tm1Yiw mutation (0 available); any Il1b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-1 beta level ( J:47429 )

• mice do not produce IL-1beta

homeostasis/metabolism

decreased circulating corticosterone level ( J:47429 )

• corticosterone levels 8 hours after injection of turpentine are elevated 2- to 3- fold in wild-type mice but not in mutant mice

• initial rises in corticosterone levels (within first 2 hours of injection) are similar to wild-type

decreased circulating interleukin-1 beta level ( J:47429 )

• mice do not produce IL-1beta

impaired febrile response ( J:47429 )

• mice fail to develop a fever in response to turpentine administration while controls have a fever 1 to 4 days after injection

Allelic Composition	Il1a^tm1Yiw/Il1a^tm1Yiw Il1b^tm1Yiw/Il1b^tm1Yiw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1a^tm1Yiw mutation (0 available); any Il1a mutation (29 available)
Il1b^tm1Yiw mutation (0 available); any Il1b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil recruitment ( J:50775 )

• neutrophil influx into the peritoneal cavity after inoculation with a tumor cell line expressing FasL is about half that of controls

hematopoietic system

impaired neutrophil recruitment ( J:50775 )

• neutrophil influx into the peritoneal cavity after inoculation with a tumor cell line expressing FasL is about half that of controls

Allelic Composition	Il1a^tm1Yiw/Il1a^tm1Yiw Il1b^tm1Yiw/Il1b^tm1Yiw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-1 alpha level ( J:47429 )

• mice do not produce IL-1alpha

decreased circulating interleukin-1 beta level ( J:47429 )

• mice do not produce IL-1beta

decreased susceptibility to type IV hypersensitivity reaction ( J:165513 )

• mice challenged with FITC and 2,4-dinitrofluorobenzene exhibit attenuated ear swelling compared with similarly treated wild-type mice

• mice challenged with methylated BSA exhibit impaired delayed-type hypersensitivity compared with similarly treated wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:165513 )

homeostasis/metabolism

decreased circulating corticosterone level ( J:47429 )

• corticosterone levels 8 hours after injection of turpentine are elevated 2- to 3- fold in wild-type mice but not in mutant mice

• initial rises in corticosterone levels (within first 2 hours of injection) are similar to wild-type

decreased circulating interleukin-1 alpha level ( J:47429 )

• mice do not produce IL-1alpha

decreased circulating interleukin-1 beta level ( J:47429 )

• mice do not produce IL-1beta

impaired febrile response ( J:47429 )

• mice fail to develop a fever in response to turpentine administration while controls have a fever 1 to 4 days after injection

Allelic Composition	Il1a^tm1Yiw/Il1a^tm1Yiw Il1b^tm1Yiw/Il1b^tm1Yiw Tg(KRT14-CASP1)1Miz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

dermatitis ( J:78602 )

• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants

integument

dermatitis ( J:78602 )

• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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