Phenotypes associated with this allele

• Allele Symbol: Apobec1^tm1Rub
• Allele Name: targeted mutation 1, Edward M Rubin
• Allele ID: MGI:2157378
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apobec1^tm1Rub/Apobec1^tm1Rub	involves: C57BL/6 * DBA	MGI:3850528
cx2	Apobec1^tm1Rub/Apobec1^tm1Rub Apoe^tm1(APOE*2)Mae/Apoe^tm1(APOE*2)Mae	involves: 129P2/OlaHsd * C57BL/6	MGI:3850531

Genotype
MGI:3850528

hm1

• Allelic Composition: Apobec1^tm1Rub/Apobec1^tm1Rub
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:74021 )

• mice exhibit an increase in low density lipoprotein fraction and a reduction in high density lipoprotein cholesterol compared to with wild-type mice

decreased circulating HDL cholesterol level ( J:74021 )

increased circulating LDL cholesterol level ( J:74021 )

Genotype
MGI:3850531

cx2

• Allelic Composition: Apobec1^tm1Rub/Apobec1^tm1Rub; Apoe^{tm1(APOE*2)Mae}/Apoe^{tm1(APOE*2)Mae}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:79196 )

• 60% in males compared to in Apoe^{tm1(APOE*2)Mae} homozygotes

decreased circulating cholesterol level ( J:79196 )

• 18% in female mice compared to in Apoe^{tm1(APOE*2)Mae} homozygotes

decreased circulating LDL cholesterol level ( J:79196 )

• in male and female mice compared to in Apoe^{tm1(APOE*2)Mae} homozygotes

increased circulating triglyceride level ( J:79196 )

• female and male mice exhibit increased serum triglyceride levels (60% and 100%) compared to in Apoe^{tm1(APOE*2)Mae} homozygotes

increased circulating VLDL triglyceride level ( J:79196 )

• compared to in Apoe^{tm1(APOE*2)Mae} homozygotes