Apoetm1(APOE*2)Mae
Targeted Allele Detail
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Symbol: |
Apoetm1(APOE*2)Mae |
Name: |
apolipoprotein E; targeted mutation 1, Nobuyo Maeda |
MGI ID: |
MGI:2158396 |
Synonyms: |
2, Apoe2, APOE*2, APOE2 TR, Apoetm1(APOE)Mae, E2, TgH/ApoE2/N8, TRE2 |
Gene: |
Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
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Alliance: |
Apoetm1(APOE*2)Mae page
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Germline Transmission: |
Earliest citation of germline transmission:
J:48565
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Apoetm1(APOE*2)Mae expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APOE (348) |
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Mutation details: A DNA fragment containing exons 2-4 of the human APOE gene (the APOE2 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable.
(J:48565)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:48565 Sullivan PM, et al., Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest. 1998 Jul 1;102(1):130-5 |
All: |
64 reference(s) |
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