About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apobec1tm1Ddsn
targeted mutation 1, Nicholas O Davidson
MGI:2157186
Summary 5 genotypes


Genotype
MGI:3623802
hm1
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Genetic
Background		 B6.129S4-Apobec1tm1Ddsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:108052 )
• chylomicron particles larger in size than in controls
abnormal triglyceride level ( J:108052 )
• accumulation of plasma triglycerides as a result of oral lipid challenge reduced in comparison to controls




Genotype
MGI:3623801
hm2
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:32731 )
• plasma triglyceride levels, cholesterol levels and cholesterol distribution in particular were normal




Genotype
MGI:4367102
cx3
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (27 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating LDL cholesterol level ( J:132734 )
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction
abnormal blood coagulation ( J:132734 )
• elevated thrombin and antithrombin levels
decreased partial thromboplastin time ( J:132734 )
• shortened activated thromboplastin times
decreased prothrombin time ( J:132734 )
• shortened prothrombin times

cardiovascular system
atherosclerotic lesions ( J:132734 )
• plaque surface area increases from 24 to 72 weeks of age
• plaques composed of a fibrous cap over a foam cell core
• multilayered smooth muscle cell regions associated with collagen deposition at 24 weeks
• smooth muscle cell numbers diminished after 36 weeks
• collagen throughout the plaque core at 48 weeks




Genotype
MGI:4367109
cx4
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Fggtm1Fjc/Fggtm1Fjc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (27 available)
Fggtm1Fjc mutation (0 available); any Fgg mutation (30 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:135942 )
• display better survival to 3 weeks than do mice only deficient for Fgg

homeostasis/metabolism
increased circulating LDL cholesterol level ( J:132734 )
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction
abnormal blood coagulation ( J:132734 )
• thrombin and antithrombin levels very highly elevated

cardiovascular system
atherosclerotic lesions ( J:132734 )
• plaque surface area increases beyond what is seen in double homozygotes lacking fibrinogen gamma chain deficiency
• fibrous cap thinner than is seen in double homozygotes lacking fibrinogen gamma chain deficiency
• collagen deposition in plaques develops more rapidly than in double homozygotes lacking fibrinogen gamma chain deficiency




Genotype
MGI:4367101
cx5
Allelic
Composition		 Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (27 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:49125 )
• total cholesterol levels are higher in males than females
• on a high fat diet total cholesterol reaches 1600 mg/dl by 8 weeks
increased circulating LDL cholesterol level ( J:49125 )
• elevated in both sexes but higher in males than females

cardiovascular system
atherosclerotic lesions ( J:49125 )
• extensive lesions along the length of the aorta at 8 months
• lesions are somewhat more extensive in males but otherwise the sexes are similar
• on a high fat diet lesions cover 9% of the aorta surface by 8 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
familial hypercholesterolemia DOID:13810 OMIM:143890
 J:49125




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory