Phenotypes associated with this allele

• Allele Symbol: Apoa4^tm1Bres
• Allele Name: targeted mutation 1, Jan L Breslow
• Allele ID: MGI:2157162
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoa4^tm1Bres/Apoa4^tm1Bres	B6.129S4-Apoa4^tm1Bres	MGI:3698749
hm2	Apoa4^tm1Bres/Apoa4^tm1Bres	either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)	MGI:3698746
cx3	Apoa4^tm1Bres/Apoa4^tm1Bres Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5051942

Genotype
MGI:3698749

hm1

• Allelic Composition: Apoa4^tm1Bres/Apoa4^tm1Bres
• Genetic Background: B6.129S4-Apoa4^tm1Bres

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:91357 )

• increased severity of colitis experimentally induced by providing sodium dextran sulfate in the drinking water

immune system

increased susceptibility to induced colitis ( J:91357 )

• increased severity of colitis experimentally induced by providing sodium dextran sulfate in the drinking water

Genotype
MGI:3698746

hm2

• Allelic Composition: Apoa4^tm1Bres/Apoa4^tm1Bres
• Genetic Background: either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)

homeostasis/metabolism

abnormal lipid homeostasis ( J:43015 )

• decreased triglyceride transport rate

decreased circulating triglyceride level ( J:43015 )

• reduced 45%

• levels are tied more to Apoa3 levels (which are also reduced) than to Apoa4 levels

decreased circulating VLDL triglyceride level ( J:43015 )

• reduced 61%

abnormal cholesterol homeostasis ( J:43015 )

• 27% increase in the HDL-cholesterol ester catabolic rate

decreased circulating cholesterol level ( J:43015 )

• reduced 23% in both fed and fasted state

decreased circulating HDL cholesterol level ( J:43015 )

• reduced 23%

behavior/neurological

increased food intake ( J:43015 )

• animals fasted 18 hours before being given unlimited food had higher short term food intake than controls but the difference is only significant on a predominantly 129 background

Genotype
MGI:5051942

cx3

• Allelic Composition: Apoa4^tm1Bres/Apoa4^tm1Bres; Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

mortality/aging

premature death ( J:169682 )

• impaired survival compared to wild-type mice and transgenic mice wild-type for Apoa4

nervous system

amyloid beta deposits ( J:169682 )

• accelerated deposition compared to transgenic mice wild-type for Apoa4

neuron degeneration ( J:169682 )

• large pyramidal neurons in cortical layer 5 and neurons in hippocampus contain more disrupted morphologies indicating enhanced neuron loss compared to transgenic mice wild-type for Apoa4

• loss of neurons is increased in areas of the cortex and CA1, CA3 of the hippocampus

behavior/neurological

abnormal spatial learning ( J:169682 )

• impaired spatial learning (slower decrease in escape latency during training in a morris water maze) compared to transgenic mice wild-type for Apoa4

abnormal long-term spatial reference memory ( J:169682 )

• more time spent in the incorrect quadrant in a probe trial in a morris water maze compared to transgenic mice wild-type for Apoa4

homeostasis/metabolism

amyloid beta deposits ( J:169682 )

• accelerated deposition compared to transgenic mice wild-type for Apoa4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:169682