All Phenotypes Bcl2l11<tm1Ast> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l11^tm1Ast/Bcl2l11^tm1Ast	B6.129S1-Bcl2l11^tm1Ast	MGI:3796612
cn2	Bcl2l11^tm1Ast/Bcl2l11^tm1Ast Dicer1^tm1Bdh/Dicer1^tm1Bdh Aicda^tm1(cre)Njen/Aicda⁺	involves: 129S1/Sv * C57BL/6	MGI:5315121

Allelic Composition	Bcl2l11^tm1Ast/Bcl2l11^tm1Ast
Genetic Background	B6.129S1-Bcl2l11^tm1Ast

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1Ast mutation (0 available); any Bcl2l11 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus morphology ( J:111236 )

• 2 days after neonatal hypoxia-ischemia (HI) injury, ispsilateral hippocampal area loss (7.8%) is half of that seen in wild-type mice (16.8%) after HI

gliosis ( J:111236 )

• reactive gliosis is significantly decreased in hippocampi of mutants 2 days after neonatal HI compared to wild-type

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:181782 )

• rescued germinal center B cells cannot effectively differentiate into antibody-secreting cells (AScs), and fail to differentiate into high affinity ASCs

decreased germinal center B cell number ( J:181782 )

• numbers are reduced in spleen relative to wild-type, but are dramatically increased on a Bcl2l11-deficient background compared to conditional knockouts with wild-type background

decreased plasma cell number ( J:181782 )

• NP-specific IgG1 antibody-secreting cells (ASCs) are present only at 20-25% of the numbers observed in wild-type spleens at day 12 after immunization

• high affinity ASCs are almost undetectable and bone marrow

hematopoietic system