All Phenotypes Sema6a<Gt(KST069)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd	MGI:3795751
hm2	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6J	MGI:3037891
cn3	Chat^tm2(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr	MGI:5562538
cx4	Plxna4^tm1Matl/Plxna4⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺	involves: 129P2/OlaHsd	MGI:5007634
cx5	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Sema6b^tm1Hfu/Sema6b^tm1Hfu	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:4461294
cx6	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795752
cx7	Plxna2^tm1Hfu/Plxna2⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795755
cx8	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5562540
cx9	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Tg(Trhr-EGFP)HU193Gsat/0	involves: 129P2/OlaHsd * FVB/NTac	MGI:5562539

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:172268 , J:202884 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice (J:172268)

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other (J:202884)

• On SACs are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes (J:202884)

• On SACs have asymmetric dendritic arbors; however, Off cells develop the normal radially symmetrical dendritic pattern (J:202884)

• disruption of the dendritic plexus organization of On but not Off SACs (J:202884)

abnormal retina ganglion cell morphology ( J:172268 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

nervous system phenotype ( J:135421 )

N	• unlike mice homozygous for Plxna4^tm1Hfu no obvious abnormalities in mossy fiber projection are seen

abnormal hippocampal mossy fiber morphology ( J:160509 )

• mice exhibit abnormal projection of mossy cell axons compared to in wild-type mice

• however, the thickness of the suprapyramidal bundle is normal

abnormal neurite morphology ( J:172268 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice

abnormal dendrite morphology ( J:202884 )

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal amacrine cell morphology ( J:172268 , J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other (J:202884)

• On SACs are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes (J:202884)

• On SACs have asymmetric dendritic arbors; however, Off cells develop the normal radially symmetrical dendritic pattern (J:202884)

• disruption of the dendritic plexus organization of On but not Off SACs (J:202884)

abnormal retina ganglion cell morphology ( J:172268 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice

Allelic Composition	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:67920 )

N	• no behavioral abnormalities are observed

reproductive system

reproductive system phenotype ( J:67920 )

N	• homozygotes are viable and fertile

nervous system

abnormal forebrain morphology ( J:67920 )

• caudal thalamocortical axons project down toward the amygdala rather than up toward the cortex

• rostral thalamocortical axons project normally

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (57 available)
Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze} mutation (4 available); any Gt(ROSA)26Sor mutation (942 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:202884 )

• starburst amacrine cells in flat mount retinas show excess and aberrant light-evoked inhibitory postsynaptic currents

Allelic Composition	Plxna4^tm1Matl/Plxna4⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4^tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased sensory neuron number ( J:172268 )

• mice exhibit an increase in TH+ puncta in S4/S5 of the inner plexiform layer compared to in wild-type mice

Allelic Composition	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Sema6b^tm1Hfu/Sema6b^tm1Hfu
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (84 available)
Sema6b^tm1Hfu mutation (0 available); any Sema6b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:160509 )

• the suprapyramidal bundle is thicker and the infrapyramidal bundle is longer than in Sema6b^tm1Hfu homozygotes

• more mossy fibers aberrantly spread into the stratum radiatum and stratum oriens compared to in Sema6b^tm1Hfu homozygotes

• however, mossy fiber spread into the stratum lacunosum-moleculare is normal

• mossy fibers invade the inner molecular layer of the dentate gyrus unlike in wild-type mice

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (127 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:135421 )

N	• unlike mice homozygous for Plxna2^tm1Hfu alone mossy fiber projection is essentially normal

abnormal hippocampal mossy fiber morphology ( J:160509 )

• the suprapyramidal bundle is slightly thinner than in wild-type mice

ectopic cerebellar granule cells ( J:135408 )

• the number of ectopic granule cells in the molecular layer is not significantly different from single homozygous mice

Allelic Composition	Plxna2^tm1Hfu/Plxna2⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

ectopic cerebellar granule cells ( J:135408 )

• in the molecular layer

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

abnormal dendrite morphology ( J:202884 )

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

Allelic Composition	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Tg(Trhr-EGFP)HU193Gsat/0
Genetic Background	involves: 129P2/OlaHsd * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (84 available)
Tg(Trhr-EGFP)HU193Gsat mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal single cell response ( J:202884 )

• cell patch recording of direction-selective ganglion cells presented with drifting-bar motion stimulation show that On direction-selective tuning is compromised; however, Off response is similar to controls

• On responses have abnormal, broader, directional tuning, with the magnitudes of the response vector sums being significantly lower

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