Sema6b^tm1Hfu
Targeted Allele Detail

Summary

• Symbol: Sema6b^tm1Hfu
• Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; targeted mutation 1, Hajime Fujisawa
• MGI ID: MGI:4461232
• Gene: Sema6b Location: Chr17:56430085-56447343 bp, - strand Genetic Position: Chr17, 29.17 cM, cytoband D
• Alliance: Sema6b^tm1Hfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160509
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence spanning most of exon 2 through 7 was replaced with a floxed neo cassette and farnesylated EGFP. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:160509)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema6b Mutation: 27 strains or lines available

References

• Original: J:160509 Tawarayama H, et al., Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers. J Neurosci. 2010 May 19;30(20):7049-60
• All: 3 reference(s)