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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adora3tm1Jbsn
targeted mutation 1, Marlene A Jacobson
MGI:2155986
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adora3tm1Jbsn/Adora3tm1Jbsn B6.129P2-Adora3tm1Jbsn MGI:4943477
hm2
 		Adora3tm1Jbsn/Adora3tm1Jbsn either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * C57BL/6) MGI:2653748
hm3
 		Adora3tm1Jbsn/Adora3tm1Jbsn involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:4943461


Genotype
MGI:4943477
hm1
Allelic
Composition		 Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic
Background		 B6.129P2-Adora3tm1Jbsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora3tm1Jbsn mutation (1 available); any Adora3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating creatinine level ( J:82054 )
• following renal ischemia and reperfusion injury
abnormal response/metabolism to endogenous compounds ( J:123463 )
• mice exhibit reduced adenosine-induced airway responsiveness compared with wild-type mice
decreased susceptibility to kidney reperfusion injury ( J:82054 )
• following renal ischemia and reperfusion injury, mice exhibit decreased creatinine plasma levels and improved renal histology compared with wild-type mice
• mice are protected from myoglobinuria-induced renal failure compared with wild-type mice

vision/eye

renal/urinary system
decreased susceptibility to kidney reperfusion injury ( J:82054 )
• following renal ischemia and reperfusion injury, mice exhibit decreased creatinine plasma levels and improved renal histology compared with wild-type mice
• mice are protected from myoglobinuria-induced renal failure compared with wild-type mice

immune system
abnormal mast cell degranulation ( J:123463 )
• mice fail to exhibit adenosine-induced mast cell degranulation unlike wild-type mice
impaired neutrophil recruitment ( J:123463 )
• mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice

respiratory system
decreased airway responsiveness ( J:123463 )
• mice exhibit reduced adenosine-induced airway responsiveness, mast cell degranulation, and neutrophil recruitment compared with wild-type mice

hematopoietic system
abnormal mast cell degranulation ( J:123463 )
• mice fail to exhibit adenosine-induced mast cell degranulation unlike wild-type mice
impaired neutrophil recruitment ( J:123463 )
• mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice

cellular
abnormal mast cell degranulation ( J:123463 )
• mice fail to exhibit adenosine-induced mast cell degranulation unlike wild-type mice




Genotype
MGI:2653748
hm2
Allelic
Composition		 Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora3tm1Jbsn mutation (1 available); any Adora3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:60293 )
• mutants exhibit ablation of adenosine or 2-CI-IB-MECA potentiation of antigen-stimulated BMMC degranulation
decreased tumor necrosis factor secretion ( J:60293 )
• reduced LPS-induced TNFalpha production

hematopoietic system
abnormal mast cell physiology ( J:60293 )
• mutants exhibit ablation of adenosine or 2-CI-IB-MECA potentiation of antigen-stimulated BMMC degranulation




Genotype
MGI:4943461
hm3
Allelic
Composition		 Adora3tm1Jbsn/Adora3tm1Jbsn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora3tm1Jbsn mutation (1 available); any Adora3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased coronary flow rate ( J:77069 )
• mice exhibit augmented adenosine-induced coronary flow compared with similarly treated wild-type mice
decreased myocardial infarct size ( J:103737 )
• following coronary artery occlusion and reperfusion with less neutrophil accumulation
decreased systemic arterial blood pressure ( J:61026 )
• following infusion with adenosine

homeostasis/metabolism
decreased myocardial infarct size ( J:103737 )
• following coronary artery occlusion and reperfusion with less neutrophil accumulation
abnormal response/metabolism to endogenous compounds ( J:61026 , J:77069 )
• following infusion with adenosine, mice exhibit reduced blood pressure compared with wild-type mice (J:61026)
• mice exhibit augmented adenosine-induced coronary flow compared with similarly treated wild-type mice (J:77069)

behavior/neurological
abnormal nociception after inflammation ( J:120442 )
• mice exhibit decreased heat hyperalgesia following carrageenan injection compared with similarly treated wild-type mice

immune system
decreased acute inflammation ( J:120442 )
• mice injected with carrageenan exhibit decreased paw edema compared with similarly treated wild-type mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory