Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(6Snca)1Slab mutation
(1 available);
any
Del(6Snca)1Slab mutation
(1 available)
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nervous system
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• no signs of Parkinsonism in mice up to ages beyond 1 year
• resistant to the effects of metamphetamine on dopamine and DOPAC levels
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• protein levels of sideroflexin 3 (SFXN3, a mitochondrial protein localized to the inner mitochondrial membrane) are significantly upregulated in synaptosomes relative to those in C57BL/6J control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(6Snca)1Slab mutation
(1 available);
any
Del(6Snca)1Slab mutation
(1 available)
Tg(Camk2a-SNCA*)2Mgsp mutation
(0 available)
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behavior/neurological
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• in the Barnes maze, mice do not show a difference in latency to find the target hole across 5 days of testing, however they show an increase in the number of errors at days 3 and 4, indicating a partial learning impairment
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• in the Barnes maze, mice show a deficit in their memory for the correct location of the target escape hole in the probe trial
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• in the novel object recognition test, mice at 3 months of age spend less time exploring the novel object, which becomes more pronounced at 6 months of age
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nervous system
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• accumulation of the transgenic alpha-synuclein protein in the forebrain
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taste/olfaction
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• in the buried food test, mice show a slight but significant delay in the time spent to locate the food pellet at 1 month of age, but not at 3 or 4 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(6Snca)1Slab mutation
(1 available);
any
Del(6Snca)1Slab mutation
(1 available)
Tg(Th-SNCA*)1Mgsp mutation
(0 available)
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behavior/neurological
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• at 18 months, mice show significantly reduced spontaneous activity relative to non-transgenic controls
• at 18 months, mice exhibit an enhanced locomotor response to amphetamine treatment compared to controls
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hematopoietic system
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• increased number of microglial cells associated with affected brain regions
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immune system
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• increased number of microglial cells associated with affected brain regions
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nervous system
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• increased number of microglial cells associated with affected brain regions
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• at 12-14 months of age, neurons show pathological changes including dense, shrunken perikarya, beaded or dystrophic processes, as well as perinuclear or very localized inclusions
• deep inclusions are observed in cytoplasm of dopaminergic neurons
• granular deposits and vacuolation of the cytoplasm are detected in older mice
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• dopaminergic axons in the striatum appear with focal varicose swellings and seem to have larger diameters than littermate controls
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• mutant human alpha-synuclein protein accumulates in inclusion-like structures in substatia nigra and olfactory bulb at all ages studied
• by 3 months, alpha-synuclein protein accumulates in the somatodendritic compartment
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homeostasis/metabolism
Analysis Tools