All Phenotypes Cyp1b1<tm1Gonz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cyp1b1^tm1Gonz
targeted mutation 1, Frank J Gonzalez
MGI:2154690

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz	129X1.Cg-Cyp1b1^tm1Gonz	MGI:3655821
hm2	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz	B6.Cg-Cyp1b1^tm1Gonz	MGI:3655820
hm3	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz	involves: 129X1/SvJ * C57BL/6	MGI:3640331
hm4	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz	involves: 129X1/SvJ * C57BL/6J	MGI:3655819
hm5	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz	involves: 129X1/SvJ * C57BL/6N	MGI:3640330
cx6	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz Tyr^c-2J/Tyr^c-2J	B6.Cg-Tyr^c-2J Cyp1b1^tm1Gonz	MGI:3655823

Allelic Composition	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz
Genetic Background	129X1.Cg-Cyp1b1^tm1Gonz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1^tm1Gonz mutation (4 available); any Cyp1b1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iridocorneal angle ( J:82280 )

• Background Sensitivity: in congenic albino 129X1 background, more severe and extensive angle abnormalities are present compared to albino congenic B6 background

abnormal canal of Schlemm morphology ( J:82280 )

• small Schlemm's canal

hypoplastic trabecular meshwork ( J:82280 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280

Allelic Composition	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz
Genetic Background	B6.Cg-Cyp1b1^tm1Gonz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1^tm1Gonz mutation (4 available); any Cyp1b1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iridocorneal angle ( J:82280 )

• Background Sensitivity: in pigmented B6 background, more mild and focal angle abnormalities are present compared to albino 129X1 background

abnormal canal of Schlemm morphology ( J:82280 )

• small Schlemm's canal

hypoplastic trabecular meshwork ( J:82280 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280

Allelic Composition	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1^tm1Gonz mutation (4 available); any Cyp1b1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:81113 )

• almost complete protection from the acute bone marrow cytotoxic and preleukemic effects of the DMBA

Allelic Composition	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1^tm1Gonz mutation (4 available); any Cyp1b1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iridocorneal angle ( J:82280 )

• angle abnormalities are present focally, detectable only by historical and electron microscopic analyses

• no gross abnormality observed

• intraocular pressure is indistinguishable from that of normal littermates

• in this mixed background, albino homozygous mice show more severe angle defects than pigmented homozygous mice

absent Schlemm's canal ( J:82280 )

• a small or absent Schlemm's canal

abnormal trabecular meshwork morphology ( J:82280 )

• basal lamina extends from the cornea over the trabecular meshwork

anterior iris synechia ( J:82280 )

• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280

Allelic Composition	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz
Genetic Background	involves: 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1^tm1Gonz mutation (4 available); any Cyp1b1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:53827 )

• only 7.5% (vs. 70% in control) of mutant mice developed highly malignant lymphomas by administration of high level of DMBA

• incident of skin hyperplasia and tumors induced by DMBA are also reduced

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:53827 )

• only 7.5% (vs. 70% in control) of mutant mice developed highly malignant lymphomas by administration of high level of DMBA

• incident of skin hyperplasia and tumors induced by DMBA are also reduced

Allelic Composition	Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz Tyr^c-2J/Tyr^c-2J
Genetic Background	B6.Cg-Tyr^c-2J Cyp1b1^tm1Gonz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1^tm1Gonz mutation (4 available); any Cyp1b1 mutation (26 available)
Tyr^c-2J mutation (25 available); any Tyr mutation (375 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iridocorneal angle ( J:82280 )

• Background Sensitivity: albino Tyr^c-2J homozygous mice have severe and more extensive angle developmental defects than pigmented Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz mice

• L-dopa administered via pregnant mother throughout ocular development prevents the severe angle dysgenesis

absent Schlemm's canal ( J:82280 )

• a small or absent Schlemm's canal

abnormal trabecular meshwork morphology ( J:82280 )

• basal lamina extends from the cornea over the trabecular meshwork

anterior iris synechia ( J:82280 )

• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280

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