Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
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mortality/aging
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• die between E8.5 and E9.5
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cardiovascular system
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• yolk sacs lack defined vascularization
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• posterior region of the forming heart tube fails to fuse
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• heart tube forms but looping is abnormal
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embryo
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• yolk sacs lack defined vascularization
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• fail to undergo turning at the 8-somite stage
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• by E8.5, begin to show delayed growth
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• neural tubes are often crooked
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• amnion appears thickened and fails to completely enclose the body of the embryo, resulting in abnormal fusion of the amniotic and exocoelomic cavities
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• yolk sacs have a rough, folded appearance in the area of contact with the ectoplacental cone
• show separation between the endodermal and mesodermal layers and the outer endodermal layer is extensively folded
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nervous system
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• neural tubes are often crooked
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growth/size/body
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• by E8.5, begin to show delayed growth
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Allelic Composition |
Hand1tm1Eno/Hand1+
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Genetic Background |
involves: 129S7/SvEvBrd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
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Allelic Composition |
Hand1tm1Eno/Hand1tm2Eno
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Genetic Background |
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Hand1tm2Eno mutation
(0 available);
any
Hand1 mutation
(14 available)
|
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Hand1tm2Eno mutation
(0 available);
any
Hand1 mutation
(14 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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mortality/aging
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• most mutants die within 3 days of birth with only 4% surviving to P10 and less than 2% reaching adulthood
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cardiovascular system
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• immature endocardial cushions are seen in mutant hearts at E13.5
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• hyperplastic atrioventicular valves are seen in all mutants and these valves are thickened in neonates
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• 90% of mutants have membranous ventricular septal defects and these defects can be detected as early as E10.5
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• the muscular ventricular septum is thickened and disorganized
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• at E11.5 and E13.5 the left ventricle is reduced in size, however the size is normal at birth
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Hand1tm2Eno mutation
(0 available);
any
Hand1 mutation
(14 available)
Tg(Nkx2-5-cre)9Eno mutation
(0 available)
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mortality/aging
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• most mutants die within 2-4 days of birth
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cardiovascular system
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• heart defects similar to those seen in compound heterozygotes hemizygous for Tg(Myhca-cre)2182Mds are found
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Hand1tm2Eno mutation
(0 available);
any
Hand1 mutation
(14 available)
Rr133tm1Eno mutation
(0 available);
any
Rr133 mutation
(0 available)
Tg(Nkx2-5-cre)9Eno mutation
(0 available)
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mortality/aging
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• no mutant embryos are found after E10.5
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cardiovascular system
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• at E10.5 the myocardium is poorly trabeculated
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• at E10.5 the myocardium is thin
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embryo
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• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1
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muscle
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• at E10.5 the myocardium is poorly trabeculated
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• at E10.5 the myocardium is thin
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growth/size/body
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• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Hand1tm2Eno mutation
(0 available);
any
Hand1 mutation
(14 available)
Rr133tm1Eno mutation
(0 available);
any
Rr133 mutation
(0 available)
Tg(Nkx2-5-cre)9Eno mutation
(0 available)
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mortality/aging
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• no mutant embryos are found after E9.0
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cardiovascular system
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• at E9.0 some segments of the myocardial wall contain cells that resemble mesenchymal cells rather than cardiomyocytes
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• at E9.0 only a single atrium is present
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• at E9.0 only a single immature ventricle is present and the lumen of the ventricle is abnormally narrow
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muscle
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• at E9.0 some segments of the myocardial wall contain cells that resemble mesenchymal cells rather than cardiomyocytes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Hand2os1em1Eno mutation
(0 available);
any
Hand2os1 mutation
(0 available)
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mortality/aging
cardiovascular system
growth/size/body
embryo
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation
(1 available);
any
Hand1 mutation
(14 available)
Rr133tm1Eno mutation
(0 available);
any
Rr133 mutation
(0 available)
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mortality/aging
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• no mutant embryos are found after E9.5
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cardiovascular system
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• the myocardium is poorly developed at E9.0
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• at E9.0 only a single ventricle is present and the size of the ventricular lumen is decreased compared to Hand2 homozygotes as a result of an increase in the amount of cardiac jelly
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muscle
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• the myocardium is poorly developed at E9.0
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