All Phenotypes Fgfr1<tm6.1Jrt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgfr1^tm6.1Jrt
targeted mutation 6.1, Janet Rossant
MGI:2153352

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr1^tm6.1Jrt/Fgfr1^tm6.1Jrt	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2181574
ht2	Fgfr1^tm1Jrt/Fgfr1^tm6.1Jrt	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2181575
cn3	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm6.1Jrt/Fgfr1^tm1Jpa	involves: 129	MGI:6116894

Allelic Composition	Fgfr1^tm6.1Jrt/Fgfr1^tm6.1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm6.1Jrt mutation (0 available); any Fgfr1 mutation (221 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:49154 )

abnormal sternocostal joint morphology ( J:49154 )

• R7 (45%) is not attached to the sternum of newborn mice

rib fusion ( J:49154 )

• rib fusion (21%) occurs in newborn mice

abnormal vertebrae morphology ( J:49154 )

• vertebral transformations to posterior direction

• however, the number of caudal vertebrae is not reduced

thoracic vertebral transformation ( J:49154 )

• transformations of T1 to T2 (9.1%), T12 to L1 (4.5%), and T13 to L1 (55%)

cervical vertebral transformation ( J:49154 )

• transformations of C5 to C6 (9.1%), C6 to C7 (13.6%), and C7 to T1 (59%)

lumbar vertebral transformation ( J:49154 )

• transformation of L5 to S1 (4.5%) and L6 to S1 (73%)

sacral vertebral transformation ( J:49154 )

• transformation of S1 to S2 (59%) and S3 to S4 (23%)

Allelic Composition	Fgfr1^tm1Jrt/Fgfr1^tm6.1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jrt mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr1^tm6.1Jrt mutation (0 available); any Fgfr1 mutation (221 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:49154 )

rib fusion ( J:49154 )

• rib (27%) fusion occurs in newborn mice

abnormal vertebrae morphology ( J:49154 )

• vertebral transformations to posterior direction

• however, the number of caudal vertebrae is not reduced

thoracic vertebral transformation ( J:49154 )

• transformations of T1 to T2 (11%), T12 to L1 (44%), and T13 to L1 (11%)

cervical vertebral transformation ( J:49154 )

• transformations of C5 to C6 (22%), C6 to C7 (11%), and C7 to T1 (44%)

lumbar vertebral transformation ( J:49154 )

• transformations of L5 to S1 (11%) and L6 to S1 (55%)

sacral vertebral transformation ( J:49154 )

• transformations of S1 to S2 (44%) and S3 to S4 (28%)

Allelic Composition	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm6.1Jrt/Fgfr1^tm1Jpa
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr1^tm6.1Jrt mutation (0 available); any Fgfr1 mutation (221 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (88 available)
Fgfr3^tm6.1Cxd mutation (0 available); any Fgfr3 mutation (52 available)
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:242687 )

N	• brain morphology at E12.5

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