Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col10a1tm1Ksec mutation
(0 available);
any
Col10a1 mutation
(27 available)
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Altered trabecular morphology and organization in the growth plate of Col10a1tm1Ksec/Col10a1tm1Ksec mice
skeleton
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• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)
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• at P2, the resting zone of chondrocytes of the growth plate in femurs is reduced 18% to 25% compared to in wild-type mice
• at P2, mice exhibit an increase in the amount of matrix vesicles and proteoglycan-like material in the resting and proliferating zones while the quantity of matrix vesicles and proteoglycan-like material in the upper hypertrophic zone is reduced compared with wild-type mice
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• at P2 but not 4 weeks, the femur shaft mineral content is decreased compared with wild-type femurs
• at 4 weeks the mineral content of the femur head is decreased compared with wild-type femurs
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• at P2, the trabecular zone is more compact, has reduced bony material, and has reduced bone marrow space compared to in wild-type mice
• the trabecular zone exhibits increased compaction over time
• Background Sensitivity: alterations in trabecular zone are more obvious than in mice with a mixed background
• mineral distribution in the trabeculae is irregular and patchy compared to in wild-type mice
• at 4 weeks, trabecular bone content is greater than in wild-type mice
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limbs/digits/tail
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• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col10a1tm1Ksec mutation
(0 available);
any
Col10a1 mutation
(27 available)
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skeleton
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)
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• reduce trabecular bone mineral content in female mice at 1 month
• however, mineralization is normal at 1 year
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• reduce trabecular bone mineral density in female mice at 1 month
• however, mineralization is normal at 1 year
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• Background Sensitivity: trabecular bone abnormalities are not as obvious as in mcie with a pure 129S/SvEv background
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• at P2 but not 4 weeks, the femur shaft mineral content is decreased compared with wild-type femurs
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• at 4 weeks, mice exhibit a 17% reduction in articular cartilage thickness compared with wild-type mice
• Background Sensitivity: mice exhibit a greater decrease in articular cartilage thickness compared to mice on a pure 129S/SvEv background
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• at P2, the resting zone of chondrocytes of the growth plate in femurs is reduced 18% to 25% compared to in wild-type mice
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• in newborn female mice with increased cell numbers
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hematopoietic system
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• isolated naive CD4+ T helper cells are primed to differentiate into T-helper 2 cells
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• decreased CD11c+ dendritic cells at 1 month and 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 month and 1 year in the spleen
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limbs/digits/tail
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)
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immune system
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• isolated naive CD4+ T helper cells are primed to differentiate into T-helper 2 cells
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• decreased CD11c+ dendritic cells at 1 month and 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 month and 1 year in the spleen
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• phytohaemagglutinin-L (PHA-L)-activated T cells fail to secrete IL10 levels unlike wild-type cells
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• lipopolysaccharide (LPS)-stimulated B cells fail to produce IL17
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• lipopolysaccharide (LPS)-stimulated B cells fail to produce IL2 unlike wild-type cells
• phytohaemagglutinin-L-activated T cells secrete reduced IL2 levels compared with wild-type cells
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• lipopolysaccharide (LPS)-stimulated B cells fail to produce IL4 unlike wild-type cells
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• phytohaemagglutinin-L (PHA-L)-activated T cells secrete increased IL4 levels compared with wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation
(0 available);
any
Anxa5 mutation
(22 available)
Anxa6tm1Moss mutation
(2 available);
any
Anxa6 mutation
(42 available)
Col10a1tm1Ksec mutation
(0 available);
any
Col10a1 mutation
(27 available)
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immune system
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• decreased CD11c+ dendritic cells at 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 year in the spleen
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skeleton
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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• with increased cell numbers
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limbs/digits/tail
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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hematopoietic system
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• decreased CD11c+ dendritic cells at 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 year in the spleen
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Analysis Tools