All Phenotypes Igf2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf2⁺
wild type
MGI:2152991

Summary

36 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igf2^tm1Wrk/Igf2⁺	involves: 129P2/Ola * C57BL/6J	MGI:2677134
ht2	Igf2^tm4.1Wrk/Igf2⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7	MGI:5310743
ht3	Igf2^tm4Wrk/Igf2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5310734
ht4	Igf2^tm1Snha/Igf2⁺	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4880746
ht5	Igf2^tm2Wrk/Igf2⁺	involves: 129S1/Sv * C57BL/6	MGI:3529532
ht6	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3583358
ht7	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * BALB/c	MGI:2677281
ht8	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * C57BL/6 * DBA/2J	MGI:2677285
ht9	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * C57BL/6J	MGI:3845906
ht10	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * MF1	MGI:2677279
ht11	Igf2^tm1Rob/Igf2⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820254
ht12	Igf2^tm3Wrk/Igf2⁺	Not Specified	MGI:3529534
cx13	Igf1^tm1Arge/Igf1^tm1Arge Igf2^tm1Rob/Igf2⁺	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	MGI:3629689
cx14	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3629680
cx15	H19^tm1Tilg/H19⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3639341
cx16	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3845905
cx17	Gpc3^tm1Arge/Gpc3⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629782
cx18	Gpc3^tm1Arge/Y Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629874
cx19	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Stw/Igf2r⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3845907
cx20	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820262
cx21	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820276
cx22	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820277
cx23	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820278
cx24	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820279
cx25	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820295
cx26	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820297
cx27	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820303
cx28	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820304
cx29	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820307
cx30	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820308
cx31	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820259
cx32	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820255
cx33	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820263
cx34	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820257
cx35	Igf2^tm1Kel/Igf2⁺ Phlda2^tm1Bty/Phlda2⁺	involves: 129/Sv * C57BL/6	MGI:3042598
cx36	Igf2^tm1Kel/Igf2⁺ Phlda2^tm2Bty/Phlda2⁺	involves: 129/Sv * C57BL/6	MGI:3042599

Allelic Composition	Igf2^tm1Wrk/Igf2⁺
Genetic Background	involves: 129P2/Ola * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Wrk mutation (0 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:77386 )

• intrauterine growth retardation following onset of reduced placental growth

small placenta ( J:77386 , J:90697 )

• reduced placental growth (J:77386)

• placental maternal and fetal side-surface areas are reduced about 50% and harmonic mean thickness (a measure that emphasizes the presence of thin areas) is increased 128% compared to wild-type (J:90697)

decreased placenta weight ( J:90697 )

• placental weight is reduced to 72% and 66% of wild-type at E16 and E19 respectively

abnormal placental transport ( J:77386 , J:90697 )

• increased active transport initially compensates for reduction in permeability but by E19 this compensation no longer functions (J:77386)

• diffusion across the placenta is significantly reduced at E16 and over a greater range solute sizes at E19 at which time diffusion across the placenta is 45% of wild-type (J:90697)

growth/size/body

decreased birth body size ( J:65001 )

• mutants with a paternally inherited allele exhibit intrauterine growth retardation, with birth weights 71% that of normal mice

abnormal postnatal growth ( J:65001 )

• mutants with a paternally inherited allele, exhibit accelerated postnatal growth such that pups attain the weight of controls after weaning

abnormal prenatal growth/weight/body size ( J:77386 )

embryonic growth retardation ( J:77386 )

• intrauterine growth retardation following onset of reduced placental growth

decreased fetal weight ( J:90697 )

• fetal weight is reduced to 94% and 76% of wild-type at E16 and E19 respectively

cellular

maternal imprinting ( J:65001 , J:90697 )

Allelic Composition	Igf2^tm4.1Wrk/Igf2⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm4.1Wrk mutation (2 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:178292 )

• when the repressor site-disrupted allele is maternally inherited, its expression in 12.5-17.5 days post coitus (dpc) embryos (detected by RT-PCR followed by restriction enzyme digestion of the cDNA to distinguish it from that from the paternally inherited M. spretus allele) is ~3-fold that of the normally repressed wild-type maternal allele in control embryos.

• when the disrupted allele is paternally inherited, its expression level does not appear to differ significantly from that of the highly expressed wild-type paternal allele of control embryos.

Allelic Composition	Igf2^tm4Wrk/Igf2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm4Wrk mutation (2 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:169366 )

• maternal transmission of the repressor binding site-disrupted allele results in the loss of Igf2 imprinting (i.e. reactivation of the normally silent maternal allele) in mesodermal tissues; the degree of reactivation was not fully characterised but is observed (by RT-PCR) in tissues such as lung and heart.

• paternal transmission of the disrupted repressor binding site results in down-regulation of the placental-specific Igf2 transcript P0.

growth/size/body

decreased birth weight ( J:169366 )

• the birth weight of pups inheriting the floxed neo^r-disrupted repressor binding site allele paternally is ~24% that of wild-type neonates.

prenatal growth retardation ( J:169366 )

• paternal transmission of the neo^r-in repressor binding site disruption results in intra-uterine growth restriction (IUGR).

Allelic Composition	Igf2^tm1Snha/Igf2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Snha mutation (0 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal osteoblast differentiation ( J:167738 )

• osteoblast colony forming units from mice with a paternally inherited mutant allele are smaller and contain cells with fewer contacts and less dense packing

abnormal osteoclast differentiation ( J:167738 )

• in culture hematopoietic progenitors from mice with a paternally inherited mutant allele produce fewer large (greater than 10 nuclei) osteoclasts

• however, mutant cells transplanted into wild-type mice are able to form normal numbers of large osteoclasts

maternal imprinting ( J:167738 )

• only mice inheriting the mutant allele paternally show abnormal phenotypes

growth/size/body

embryonic growth retardation ( J:167738 )

• growth retardation is detectable as early as E10.5 in mice with a paternally inherited mutant allele

decreased birth weight ( J:167738 )

• about a 30% reduction in birth weight in mice with a paternally inherited mutant allele

postnatal growth retardation ( J:167738 )

• mice with a paternally inherited mutant allele remain growth retarded at 12 weeks of age

fetal growth retardation ( J:167738 )

• growth retardation becomes more pronounced between E13.5 and E17.5 in mice with a paternally inherited mutant allele

skeleton

abnormal skeleton morphology ( J:167738 )

• thinner and shorter bones in mice with a paternally inherited mutant allele

abnormal tibia morphology ( J:167738 )

• the bone is thinner but cortical bone thickness is increased and marrow cavity size is decreased in mice with a paternally inherited mutant allele

abnormal bone marrow cavity morphology ( J:167738 )

• marrow cavity size is decreased in mice with a paternally inherited mutant allele

decreased bone mineral density ( J:167738 )

• at 2, 3 and 12 months of age in mice with a paternally inherited mutant allele

abnormal compact bone lamellar structure ( J:167738 )

• the lamellar structure of the cortical bone is irregular and poorly formed, with poorly aligned osteocytes and incompletely formed lacunae in mice with a paternally inherited mutant allele

increased compact bone thickness ( J:167738 )

• in mice with a paternally inherited mutant allele

decreased osteoblast cell number ( J:167738 )

• in adult mice with a paternally inherited mutant allele

abnormal bone trabecula morphology ( J:167738 )

• dense and disorganized trabeculae in the femurs of mice with a paternally inherited mutant allele at 3 months of age

abnormal skeleton development ( J:167738 )

• adult mice with a paternally inherited mutant allele have reduced numbers of mesenchymal stem cells and osteoprogenitors

abnormal osteoblast differentiation ( J:167738 )

• osteoblast colony forming units from mice with a paternally inherited mutant allele are smaller and contain cells with fewer contacts and less dense packing

abnormal osteoclast differentiation ( J:167738 )

• in culture hematopoietic progenitors from mice with a paternally inherited mutant allele produce fewer large (greater than 10 nuclei) osteoclasts

• however, mutant cells transplanted into wild-type mice are able to form normal numbers of large osteoclasts

abnormal cartilage development ( J:167738 )

• the number of chondrocyte colonies formed in E11.5 limb bud mesenchymal cell cultures from mice with a paternally inherited mutant allele is reduced and colonies that do form do so more slowly and have a less mature phenotype

delayed bone ossification ( J:167738 )

• in mice with a paternally inherited mutant allele

embryo

embryonic growth retardation ( J:167738 )

• growth retardation is detectable as early as E10.5 in mice with a paternally inherited mutant allele

limbs/digits/tail

abnormal tibia morphology ( J:167738 )

• the bone is thinner but cortical bone thickness is increased and marrow cavity size is decreased in mice with a paternally inherited mutant allele

hematopoietic system

abnormal osteoclast differentiation ( J:167738 )

• in culture hematopoietic progenitors from mice with a paternally inherited mutant allele produce fewer large (greater than 10 nuclei) osteoclasts

• however, mutant cells transplanted into wild-type mice are able to form normal numbers of large osteoclasts

immune system

abnormal osteoclast differentiation ( J:167738 )

• in culture hematopoietic progenitors from mice with a paternally inherited mutant allele produce fewer large (greater than 10 nuclei) osteoclasts

• however, mutant cells transplanted into wild-type mice are able to form normal numbers of large osteoclasts

Allelic Composition	Igf2^tm2Wrk/Igf2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm2Wrk mutation (0 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:94521 )

• with paternal transmission, up to 50% of mutants were smaller at birth than wild-type

• with maternal transmission, mutants were normal in size and did not express significant amounts of LacZ indicating that activation of the silent maternal allele did not occur

cellular

maternal imprinting ( J:94521 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:75054 , J:10453 , J:11007 , J:15108 , J:25091 )

• 40% reduction in body weight relative to wild-type littermates but only when the mutated allele is inherited paternally (J:10453)

• the rate of postnatal growth was similar to that of wild-type (J:10453)

• viable dwarfs with body weight 60% of normal when the mutated allele is inherited paternally (J:15108)

skeleton

delayed bone ossification ( J:15108 )

• when the mutated allele is inherited paternally, mutants exhibit a one day developmental delay in hyoid, cervical, and lumbar vertebrae, radius, ulna, femur, digits, nasal bone, and all cranial bones, except for the frontal and temporal bones

cellular

maternal imprinting ( J:11007 , J:15108 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:11007 )

• only when the mutated allele is inherited paternally

cellular

maternal imprinting ( J:11007 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:11007 )

• but only when the mutated allele is inherited paternally

cellular

maternal imprinting ( J:11007 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, mice do not survive postnatally

lethality throughout fetal growth and development, incomplete penetrance ( J:77413 )

• some mice die between E14.5 and E18.5

cardiovascular system

abnormal heart morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles unlike in wild-type mice

abnormal heart septum morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, sinusoids are observed in the septa unlike in wild-type mice

increased heart weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

abnormal heart ventricle morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the number of sinusoids in the ventricles is increased compared to in wild-type mice

increased fetal cardiomyocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice

vision/eye

abnormal lens morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, minor lens abnormalities are observed

delayed eyelid fusion ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 5 of 14 mice have open eyelids at E16.5

embryo

increased placenta weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, placenta weight is 140% of wild-type mice at E15.5

endocrine/exocrine glands

adrenal gland cyst ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 1 of 3 mice develops a few small cysts

growth/size/body

increased heart weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

adrenal gland cyst ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 1 of 3 mice develops a few small cysts

omphalocele ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 7 to 22 mice exhibit mild omphalocele consisting of a protrusion of only a small portion of the liver or of a mild herniation of only the gut

increased fetal weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, mice weight 140% of normal at E18.5

increased liver weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

homeostasis/metabolism

abnormal circulating hormone level ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, serum insulin-like growth factor II levels are increase compared to in wild-type mice

limbs/digits/tail

polydactyly ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, penetrance of type A and B postaxial polydactyly is incomplete with either a small extra digit that contains a single phalangeal bone or an extra digits with two phalanges

• when Igf2^tm1Rob is inherited maternally, a minority of mice exhibit preaxial polydactyly with doubling or bifurcation of the distal phalanx of the pollex associated with postaxial polydactyly

liver/biliary system

increased hepatocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

increased liver weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

muscle

increased fetal cardiomyocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice

skeleton

abnormal sternum morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the ossification centers of the fourth sternebra are not fused along the midline and are underdeveloped compared to in wild-type mice at E17.5

abnormal xiphoid process morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the xiphisternum has unfused centers and is very broad compared to in wild-type mice

abnormal lumbar vertebrae morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the twin ossification centers in L3 are fused at E16.5

renal/urinary system

decreased kidney weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

cellular

increased fetal cardiomyocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice

increased hepatocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:11007 )

• but only when the mutated allele is inherited paternally

cellular

maternal imprinting ( J:11007 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

• however, when this allele is inherited maternally mice exhibit normal placenta weight

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf2^tm3Wrk/Igf2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm3Wrk mutation (0 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:94521 )

• following paternal transmission, mutants were 17% smaller at birth than wild-types

• following maternal transmission, mice were normal in size and expressed normal levels of Igf2 from their paternal allele, while the maternal allele remained silent

cellular

maternal imprinting ( J:94521 )

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Arge mutation (2 available); any Igf1 mutation (27 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die shortly after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit the same developmental delays in the ossification of particular bones as the Igf1r^tm1Arge single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

thin epidermis stratum spinosum ( J:15108 )

• the stratum spinosum is underdeveloped in double mutants with a paternally inherited Igf2 allele

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

nervous system

abnormal nervous system morphology ( J:15108 )

• the central nervous system of double mutants with a paternally inherited Igf2 allele exhibits the same high cellular density seen in Igf1r single mutants

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• delays in bone development are somewhat more pronounced in double mutants with a paternally inherited Igf2 allele than in Igf1r single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

abnormal epidermal layer morphology ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit an underdeveloped epidermis similar to that seen in Igf1r single mutants

Allelic Composition	H19^tm1Tilg/H19⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19^tm1Tilg mutation (1 available); any H19 mutation (16 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:25091 )

N	• indistinguishable in size from wild-type in birth weights and postnatal growth rates

Allelic Composition	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)
Rr28^tm1Tilg mutation (0 available); any Rr28 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:77413 )

• when each allele is inherited maternally, mice begin to die at E14.5 and are all dead by E18.5

cardiovascular system

abnormal myocardium layer morphology ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles and atria unlike in wild-type mice

abnormal heart septum morphology ( J:77413 )

• when each allele is inherited maternally, sinusoids are observed in the septa unlike in wild-type mice

increased heart weight ( J:77413 )

• when each allele is inherited maternally

abnormal heart ventricle morphology ( J:77413 )

• when each allele is inherited maternally, the number of sinusoids in the ventricles is increased compared to in wild-type mice

enlarged aortic valve ( J:77413 )

• when each allele is inherited maternally, the aortic valve is large and thickened compared to in wild-type mice

thick aortic valve ( J:77413 )

enlarged pulmonary valve ( J:77413 )

• when each allele is inherited maternally, the pulmonary valve is large and thickened compared to in wild-type mice

thick pulmonary valve ( J:77413 )

pericardial edema ( J:77413 )

• when each allele is inherited maternally, 2 of 4 mice exhibit accumulation of pericardial fluid unlike in wild-type mice

increased fetal cardiomyocyte proliferation ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice

vision/eye

abnormal lens development ( J:77413 )

• when each allele is inherited maternally, the anterior surface of the lens fiber cell fails to make contact with the interior surface of the lens epithelium at E13.5 to E17.5 leaving a position of the lumen unfilled unlike in wild-type mice

• when each allele is inherited maternally, severely affected mice exhibit abnormal suturing patterns

abnormal lens epithelium morphology ( J:77413 )

• poorly organized when each allele is inherited maternally

delayed eyelid fusion ( J:77413 )

• when each allele is inherited maternally, 12 of 13 mice have open eyelids at E16.5 and E17.5

liver/biliary system

increased hepatocyte proliferation ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

increased liver weight ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

limbs/digits/tail

polydactyly ( J:77413 )

• when each allele is inherited maternally, penetrance of type B-like postaxial polydactyly is complete with a small extra digit that contains a single phalangeal bone

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, penetrance of type A and B postaxial polydactyly is incomplete with either a small extra digit that contains a single phalangeal bone, an extra digits with two phalanges, or an extra digit with a third skeletal element

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, a minority of mice exhibit preaxial polydactyly with doubling or bifurcation of the distal phalanx of the pollex associated with postaxial polydactyly

embryo

increased placenta weight ( J:77413 )

• when each allele is inherited maternally, placenta weight is increased compared to in wild-type mice starting at E14.5

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, placenta weight is 140% of wild-type mice at E15.5

• when each allele is inherited maternally, placenta weight is 230% of wild-type at E16.5

craniofacial

cleft palate ( J:77413 )

• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate

endocrine/exocrine glands

adrenal gland cyst ( J:77413 )

• when each allele is inherited maternally, 3 of 4 mice develop adrenal gland cysts and both medullar and cortical cystic abnormalities

homeostasis/metabolism

abnormal circulating hormone level ( J:77413 )

• when each allele is inherited maternally, serum insulin-like growth factor II levels are increase more than 11-fold compared to in wild-type mice

edema ( J:77413 )

• when each allele is inherited maternally, mice exhibit an edematous external appearance

pericardial edema ( J:77413 )

• when each allele is inherited maternally, 2 of 4 mice exhibit accumulation of pericardial fluid unlike in wild-type mice

growth/size/body

increased heart weight ( J:77413 )

• when each allele is inherited maternally

cleft palate ( J:77413 )

• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate

adrenal gland cyst ( J:77413 )

• when each allele is inherited maternally, 3 of 4 mice develop adrenal gland cysts and both medullar and cortical cystic abnormalities

omphalocele ( J:77413 )

• when each allele is inherited maternally, 20 of 22 mice exhibit large omphalocele consisting of a large portion of the liver present anteriorly and intestinal loops lying posteriorly

increased fetal weight ( J:77413 )

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, mice weight 130% of normal at E18.5

• when each allele is inherited maternally, mice weigh 200% of normal at E16.5 and E17.5

increased liver weight ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

muscle

abnormal myocardium layer morphology ( J:77413 )

increased fetal cardiomyocyte proliferation ( J:77413 )

skeleton

split sternum ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, the sternum is split along the entire midline and almost duplicated in total width at E16.5

abnormal lumbar vertebrae morphology ( J:77413 )

• when each allele is inherited maternally, the twin centers in L2 are fused in the midline whereas the L3 and L4 centers remain separate at E16.5

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, the twin ossification centers in L3 are fused at E16.5

digestive/alimentary system

cleft palate ( J:77413 )

• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate

renal/urinary system

decreased kidney weight ( J:77413 )

• when each allele is inherited maternally

cellular

increased fetal cardiomyocyte proliferation ( J:77413 )

increased hepatocyte proliferation ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

Allelic Composition	Gpc3^tm1Arge/Gpc3⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Arge mutation (0 available); any Gpc3 mutation (18 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body size ( J:75054 )

• double mutants inheriting the mutant Igf2 allele paternally are larger than mice lacking Igf2

cellular

maternal imprinting ( J:75054 )

• defect is seen in double mutants that receive the Igf2 mutant allele from the father

Allelic Composition	Gpc3^tm1Arge/Y Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body size ( J:75054 )

• double mutants inheriting the mutant allele paternally are larger than mice lacking Igf2

cellular

maternal imprinting ( J:75054 )

• defect is seen in double mutants that receive the Igf2 mutant allele from the father

Allelic Composition	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Stw/Igf2r⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Stw mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)
Rr28^tm1Tilg mutation (0 available); any Rr28 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice die immediately after birth

limbs/digits/tail

polydactyly ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice exhibit postaxial polydactyly that is confined to a single forelimb

growth/size/body

increased fetal weight ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice weigh 135% of wild-type

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 73.8% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 73.8% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)
M6pr^tm1Hlk mutation (0 available); any M6pr mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 34.4% of normal

Allelic Composition	Igf2^tm1Kel/Igf2⁺ Phlda2^tm1Bty/Phlda2⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Kel mutation (0 available); any Igf2 mutation (27 available)
Phlda2^tm1Bty mutation (0 available); any Phlda2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

increased spongiotrophoblast size ( J:76871 )

• spongiotrophoblast is expanded relative to the trophoblast labyrinth

decreased placenta weight ( J:76871 )

• placental weight is decreased relative to controls but greater than in mice homozygous only forIgf2^tm1Kel

growth/size/body

decreased fetal weight ( J:76871 )

• fetal weight was decreased compared to controls

Allelic Composition	Igf2^tm1Kel/Igf2⁺ Phlda2^tm2Bty/Phlda2⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Kel mutation (0 available); any Igf2 mutation (27 available)
Phlda2^tm2Bty mutation (0 available); any Phlda2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

increased spongiotrophoblast size ( J:76871 )

• spongiotrophoblast is expanded relative to the trophoblast labyrinth

decreased placenta weight ( J:76871 )

• placental weight is decreased relative to controls but greater than in mice homozygous only forIgf2^tm1Kel-p

growth/size/body

decreased fetal weight ( J:76871 )

• fetal weight was decreased compared to controls

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