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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stiltm1Mku
targeted mutation 1, Michael R Kuehn
MGI:2152962
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stiltm1Mku/Stiltm1Mku Not Specified MGI:3036864
cx2
 		Ptch1tm1Zim/Ptch1tm1Zim
Stiltm1Mku/Stiltm1Mku 		involves: 129 MGI:3036865


Genotype
MGI:3036864
hm1
Allelic
Composition		 Stiltm1Mku/Stiltm1Mku
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stiltm1Mku mutation (0 available); any Stil mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
abnormal apoptosis ( J:55887 )
• extensive apoptosis in the dorsal midline in the neural folds and in somites

embryo
abnormal left-right axis patterning ( J:55887 )
• heart looping is randomized rather than being exclusively to the right
embryonic growth retardation ( J:55887 )
• reduced size and retarded development was apparent by E7.5-E8.5
absent floor plate ( J:55887 )
• failure of floor plate development
delayed neural tube closure ( J:55887 )
• delay or failure of the neural tube to close

nervous system
absent floor plate ( J:55887 )
• failure of floor plate development
delayed neural tube closure ( J:55887 )
• delay or failure of the neural tube to close
holoprosencephaly ( J:55887 )
• lack of any midline separation at the anterior end of the cranial neural folds

growth/size/body
embryonic growth retardation ( J:55887 )
• reduced size and retarded development was apparent by E7.5-E8.5




Genotype
MGI:3036865
cx2
Allelic
Composition		 Ptch1tm1Zim/Ptch1tm1Zim
Stiltm1Mku/Stiltm1Mku
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Zim mutation (2 available); any Ptch1 mutation (115 available)
Stiltm1Mku mutation (0 available); any Stil mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:72500 )
• homozygotes die around E9.5
• phenotype is identical to that of mice homozygous only for Siltm1Mku

cellular
abnormal apoptosis ( J:72500 )
• extensive apoptosis in the dorsal midline in the neural folds and in somites
• phenotype is identical to that of mice homozygous only for Siltm1Mku

nervous system
holoprosencephaly ( J:72500 )
• lack of any midline separation at the anterior end of the cranial neural folds
• phenotype is identical to that of mice homozygous only for Siltm1Mku




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory