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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfra1+
wild type
MGI:2152914
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gfra1tm1Jmi/Gfra1+ involves: 129X1/SvJ * C57BL/6 MGI:2175041
cn2
 		Erbb2tm1Haus/Erbb2tm1Klee
Gfra1tm3Jmi/Gfra1+
Myf5tm3(cre)Sor/Myf5+ 		involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ MGI:4456175
cx3
 		Egr3tm1Jmi/Egr3tm1Jmi
Gfra1tm3Jmi/Gfra1+ 		involves: 129X1/SvJ MGI:4456173
cx4
 		Egr3tm1Jmi/Egr3tm1Jmi
Gfra1tm3Jmi/Gfra1+
Tg(Hlxb9-GFP)1Tmj/0 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:4456172


Genotype
MGI:2175041
ht1
Allelic
Composition		 Gfra1tm1Jmi/Gfra1+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1tm1Jmi mutation (0 available); any Gfra1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
intestinal hypoperistalsis ( J:82456 )
• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system
abnormal enteric neuron morphology ( J:82456 )
• neuronal cell size is reduced by 19% in colon submucosal neurons, by 20% in colonic myenteric neurons and by 31% in small bowel myenteric neurons, however the number of myenteric and submucosal neurons in the small bowel and colon are normal
• myenteric neuron acetylcholinesterase-stained fiber counts are reduced by 11% in the small bowel and by 12% in the colon
abnormal neurotransmitter secretion ( J:82456 )
• 70-95% reduction in substance P and VIP release

integument
accelerated hair follicle regression ( J:65034 )
• exhibit accelerated catagen development, with a significant decline in the percentage of catagen II hair follicles and an increase of catagen V-VI hair follicles at P17
thin skin ( J:65034 )
• seen at P17

muscle
intestinal hypoperistalsis ( J:82456 )
• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation




Genotype
MGI:4456175
cn2
Allelic
Composition		 Erbb2tm1Haus/Erbb2tm1Klee
Gfra1tm3Jmi/Gfra1+
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2tm1Klee mutation (0 available); any Erbb2 mutation (59 available)
Gfra1tm3Jmi mutation (0 available); any Gfra1 mutation (31 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• the number of cholinergic motor neurons is decreased compared to in wild-type mice
decreased motor neuron number ( J:160727 )
• the number of cholinergic motor neurons is decreased compared to in wild-type mice
• mice exhibit a reduction in small Gfra1+ motor neurons compared with wild-type mice
• loss of gamma-motor neurons is intermediate to wild-type mice and Egr3tm1Jmi homozygotes
• mice exhibit a decrease in large diameter motor neurons compared with wild-type mice




Genotype
MGI:4456173
cx3
Allelic
Composition		 Egr3tm1Jmi/Egr3tm1Jmi
Gfra1tm3Jmi/Gfra1+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1Jmi mutation (5 available); any Egr3 mutation (20 available)
Gfra1tm3Jmi mutation (0 available); any Gfra1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• mice exhibit selective loss of small cholinergic neurons unlike wild-type mice
• total numbers of cholinergic neurons in the L4-5 section of the spinal cord is decreased compared to in wild-type mice
decreased motor neuron number ( J:160727 )
• total numbers of cholinergic neurons in the L4-5 section of the spinal cord is decreased compared to in wild-type mice




Genotype
MGI:4456172
cx4
Allelic
Composition		 Egr3tm1Jmi/Egr3tm1Jmi
Gfra1tm3Jmi/Gfra1+
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1Jmi mutation (5 available); any Egr3 mutation (20 available)
Gfra1tm3Jmi mutation (0 available); any Gfra1 mutation (31 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice
abnormal motor neuron morphology ( J:160727 )
• surviving Gfra1+ motor neurons exhibit somatic shrinkage and morphological evidence of degeneration unlike in wild-type mice
decreased motor neuron number ( J:160727 )
• Gfra1+, cholinergic, Gfa1+ HB9-GFP-, and Gfra1+ HB9-GFP+ motor neurons are reduced compared to in wild-type mice
• mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice
• however, the number of large diameter motor neurons is normal
motor neuron degeneration ( J:160727 )
• surviving Gfra1+ motor neurons exhibit somatic shrinkage and morphological evidence of degeneration unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory