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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psen2+
wild type
MGI:2152811
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Psen1tm2Shn/Psen1tm2Shn
Psen2tm1Haa/Psen2+
Tg(Msx2-cre)5Rem/0 		involves: 129S4/SvJae MGI:3525175
cx2
 		Psen1tm1Pcw/Psen1+
Psen2tm1Ber/Psen2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J MGI:3617373
cx3
 		Psen1tm1Pcw/Psen1tm1Pcw
Psen2tm1Ber/Psen2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J MGI:3617376


Genotype
MGI:3525175
cn1
Allelic
Composition		 Psen1tm2Shn/Psen1tm2Shn
Psen2tm1Haa/Psen2+
Tg(Msx2-cre)5Rem/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation (1 available); any Psen1 mutation (57 available)
Psen2tm1Haa mutation (0 available); any Psen2 mutation (32 available)
Tg(Msx2-cre)5Rem mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal hair follicle morphology ( J:94517 )
• showed a transient phenotype in embryo-deleted skin but developed a normal coat by P22 with a few abnormal looking follicles




Genotype
MGI:3617373
cx2
Allelic
Composition		 Psen1tm1Pcw/Psen1+
Psen2tm1Ber/Psen2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Pcw mutation (0 available); any Psen1 mutation (57 available)
Psen2tm1Ber mutation (0 available); any Psen2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:58465 )
• double heterozygotes are viable and phenotypically normal




Genotype
MGI:3617376
cx3
Allelic
Composition		 Psen1tm1Pcw/Psen1tm1Pcw
Psen2tm1Ber/Psen2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Pcw mutation (0 available); any Psen1 mutation (57 available)
Psen2tm1Ber mutation (0 available); any Psen2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:58465 )
• mutant embryos die between E9.5 and E13.5

embryo
small second pharyngeal arch ( J:58465 )
• at E9, mutant embryos display underdeveloped second branchial arches
abnormal neural tube morphology ( J:58465 )
• at E8.5, mutant embryos show a severe disorganization of the trunk ventral neural tube
delayed neural tube closure ( J:58465 )
• at E9, mutant embryos display a delay in the closure of the anterior neuropore
failure of somite differentiation ( J:58465 )
• at E8.5-E9, mutant embryos display a variable phenotype, ranging from no somite segmentation to the formation of highly disorganized somites

nervous system
abnormal neural tube morphology ( J:58465 )
• at E8.5, mutant embryos show a severe disorganization of the trunk ventral neural tube
delayed neural tube closure ( J:58465 )
• at E9, mutant embryos display a delay in the closure of the anterior neuropore

cardiovascular system
abnormal heart looping ( J:58465 )
• some mutant embryos exhibit heart looping delays at E8.5 and E9, whereas others show partial heart looping at E9

craniofacial
small second pharyngeal arch ( J:58465 )
• at E9, mutant embryos display underdeveloped second branchial arches




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory