Analysis Tools|
Allele Symbol Allele Name Allele ID |
Col11a1+ wild type MGI:2152731 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice
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• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice
• cartilage degeneration increases between 9 and 15 months of age
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• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice
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• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice
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• tensile stiffness in articular cartilage of the knee joint is moderately reduced compared to in wild-type mice
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• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice
• cartilage degeneration increases between 9 and 15 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| osteoarthritis | DOID:8398 | J:106282 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/20/2026 MGI 6.24 |
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