All Phenotypes Igf1<tm1Dlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/?	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:3603650
cn2	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Mx1-cre)1Cgn/0	involves: 129/Sv * C57BL/6 * CBA	MGI:2176943
cn3	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(EIIa-cre)C5379Lmgd/0	involves: 129/Sv * C57BL/6 * FVB/N	MGI:2176942
cn4	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Alb1-cre)1Dlr/0	involves: 129/Sv * C57BL/6 * FVB/N	MGI:2176949
cn5	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Alb1-cre)1Dlr/0	involves: 129/Sv * C57BL/6J * FVB/N	MGI:4430376
cn6	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Serpina1e-cre/ERT)1Sykr/0	involves: 129/Sv * C57BL/6J * FVB/N	MGI:4430378

Allelic Composition	Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/?
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Dlr mutation (2 available); any Igf1 mutation (25 available)
Igfals^tm1Yrb mutation (1 available); any Igfals mutation (32 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

growth/size/body

decreased body length ( J:79109 )

• 30% reduction in total length by 2-3 weeks of age

skeleton

abnormal limb bone morphology ( J:79109 )

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• reduced trabecular bone volume and trabecular bone density

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age

abnormal long bone epiphyseal plate proliferative zone ( J:79109 )

• reduced 15 %

decreased width of hypertrophic chondrocyte zone ( J:79109 )

• reduced 26%

decreased long bone epiphyseal plate size ( J:79109 )

• tibial growth plate height reduced by 20%

• germinal zone height increased in the tibia

limbs/digits/tail

abnormal limb bone morphology ( J:79109 )

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• reduced trabecular bone volume and trabecular bone density

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:121798 )

N	• after induction with PiPc, 6-mo-old mice exhibit no significant differences in serum and urine creatinine levels relative to control mice

decreased circulating insulin-like growth factor I level ( J:55718 , J:121798 )

• after induction with IFN at 24-28 days of age, mice exhibit a 75% reduction in serum IGF-I levels relative to control mice, still evident at 53 days of age (J:55718)

• after induction with PiPc at 4 weeks of age, mice exhibit a 80-85% reduction in serum IGF-I levels relative to control mice, still evident at 24 months of age (J:121798)

• renal IGF-II mRNA levels are reduced by 79%, suggesting that the effects of circulating IGF-I on kidney size may be mediated by renal IGF-II; however, no differences in serum IGF-II levels are observed at 9 months (J:121798)

increased circulating growth hormone level ( J:121798 )

• after induction with PiPc, mice exhibit compensatory increased circulating GH levels relative to control mice

increased urine potassium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr potassium excretion relative to control mice

increased urine sodium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr sodium excretion relative to control mice

growth/size/body

growth/size/body region phenotype ( J:55718 , J:121798 )

• after induction with IFN at 24-28 days of age, mice exhibit normal postnatal body growth up to 53 days of age relative to control mice (J:55718)

• after induction with PiPc at 4 weeks of age, mice exhibit no significant differences in body weight relative to control mice, as shown at 7 and 24 months of age (J:121798)

renal/urinary system

renal/urinary system phenotype ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit no significant differences in serum and urine creatinine levels, GFR, creatinine clearance, or 24-hr urine volume relative to control mice

• no glomerulosclerosis, vascular defects, mesangial sclerosis, or cortical fibrosis is observed at 24 months of age

increased urine potassium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr potassium excretion relative to control mice

increased urine sodium level ( J:121798 )

• after induction with PiPc, 6-mo-old mice exhibit increased 24-hr sodium excretion relative to control mice

decreased kidney weight ( J:121798 )

• after induction with PiPc, absolute and relative kidney weight is reduced in 7- and 24-month-old mice relative to control mice

cardiovascular system

increased systemic arterial systolic blood pressure ( J:121798 )

• after induction with PiPc, 7-mo-old mice exhibit increased systolic blood pressure relative to control mice

Allelic Composition	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Dlr mutation (2 available); any Igf1 mutation (25 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:49468 )

• some perinatal mortality but many survive

growth/size/body

slow postnatal weight gain ( J:49468 )

• 72% of control weight at 3 weeks of age, 68% at 6 weeks

fetal growth retardation ( J:49468 )

• fetus at E19 or E20 weighs only 69% as much as comparable controls

Allelic Composition	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Dlr mutation (2 available); any Igf1 mutation (25 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:69517 )

Allelic Composition	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Dlr mutation (2 available); any Igf1 mutation (25 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:155733 )

• male mutant LID (LID, chronic liver-specific IGF-1 deficiency) mice fed a high calorie or regular diet for 8 to 10 weeks exhibit decreased serum IGF-1 levels relative to controls

increased circulating leptin level ( J:155733 )

• LID mice fed a high calorie for 8 to 10 weeks exhibit increased serum leptin levels compared to lean LID mice (fed a regular diet)

neoplasm

decreased tumor growth/size ( J:155733 )

• male double mutant (LID, chronic liver-specific IGF-1 deficiency) mice on a high calorie diet for 10-14 weeks and injected with subcutaneous MC-39 murine colorectal carcinoma cell do not show the obesity-associated increase in local tumor growth compared to lean controls

Allelic Composition	Igf1^tm1Dlr/Igf1^tm1Dlr Tg(Serpina1e-cre/ERT)1Sykr/0
Genetic Background	involves: 129/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Dlr mutation (2 available); any Igf1 mutation (25 available)
Tg(Serpina1e-cre/ERT)1Sykr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:155733 )

N	• serum adiponectin and glucose levels in obese iLID mice are comparable to lean iLID mice (iLID, inducible liver-specific IGF-1 deficiency)

increased circulating insulin level ( J:155733 )

• iLID mice fed a high calorie for 8 to 10 weeks and then injected with tamoxifen exhibit increased serum insulin levels compared to tamoxifen-treated lean mice (fed a regular diet)

decreased circulating insulin-like growth factor I level ( J:155733 )

• mutant mice (iLID, inducible liver-specific IGF-1 deficiency) fed a high calorie or regular diet for 8 to 10 weeks and then injected with tamoxifen exhibit decreased serum IGF-1 levels relative to tamoxifen-treated controls

increased circulating leptin level ( J:155733 )

• iLID mice fed a high calorie for 8 to 10 weeks and then injected with tamoxifen exhibit increased serum leptin levels compared to tamoxifen-treated lean mice (fed a regular diet)

neoplasm

neoplasm ( J:155733 )

N	• tamoxifen treatment of lean or obese mice before or after injection of MC-38 colon carcinoma cells does not alter the obesity-associated increase in tumor growth in contrast to what is observed in LID (chronic liver-specific IGF-1 deficiency) mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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