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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lifr+
wild type
MGI:2151912
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Lifrtm1Imx/Lifr+ B6;129S7-Lifrtm1Imx/J MGI:6094214
ht2
Lifrtm1b(EUCOMM)Hmgu/Lifr+ C57BL/6N-Lifrtm1b(EUCOMM)Hmgu/H MGI:5757311


Genotype
MGI:6094214
ht1
Allelic
Composition
Lifrtm1Imx/Lifr+
Genetic
Background
B6;129S7-Lifrtm1Imx/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lifrtm1Imx mutation (1 available); any Lifr mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 42.5% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

renal/urinary system
• reduction of the proximal, medial and distal ureteric lumen at E18.5, but to a lesser extent than in homozygotes
• 5% of E18.5 fetuses exhibit severe hydroureter

reproductive system
• 42.5% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism




Genotype
MGI:5757311
ht2
Allelic
Composition
Lifrtm1b(EUCOMM)Hmgu/Lifr+
Genetic
Background
C57BL/6N-Lifrtm1b(EUCOMM)Hmgu/H
Cell Lines HEPD0662_5_B09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lifrtm1b(EUCOMM)Hmgu mutation (0 available); any Lifr mutation (59 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

nervous system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory