Phenotypes associated with this allele

• Allele Symbol: Nr2e1^tm1Gsc
• Allele Name: targeted mutation 1, Gunther Schutz
• Allele ID: MGI:2151350
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr2e1^tm1Gsc/Nr2e1^tm1Gsc	involves: 129 * C57BL/6	MGI:3807580

Genotype
MGI:3807580

hm1

• Allelic Composition: Nr2e1^tm1Gsc/Nr2e1^tm1Gsc
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:44679 )

• fail to gain weight normally over the first three weeks after birth

nervous system

abnormal cortical intermediate zone morphology ( J:44679 )

• a reduction in the number of cells in the intermediate zone of the cortex at E15.5

decreased brain size ( J:44679 )

• a visible reduction in the size of their posterior cerebral hemispheres

decreased anterior commissure size ( J:44679 )

• reduced anterior wings of anterior commissure connecting the olfactory cortices

abnormal limbic system morphology ( J:44679 )

• reduced limbic structures including the olfactory, infrarhinal and entorhinal cortex, amygdale and dentate gyrus

abnormal amygdala morphology ( J:44679 )

• reduced corticomedial amygdala

abnormal entorhinal cortex morphology ( J:44679 )

• reduced entorhinal cortex

abnormal dentate gyrus morphology ( J:44679 )

• reduced dentate gyrus associated with a reduction and an abnormal lamination of the mossy fiber projection

abnormal hippocampal mossy fiber morphology ( J:44679 )

• reduced dentate gyrus associated with a reduction and an abnormal lamination of the mossy fiber projection

decreased subiculum size ( J:44679 )

• reduced or missing presubiculum and parasubiculum

small olfactory bulb ( J:44679 )

abnormal olfactory cortex morphology ( J:44679 )

• reduced rhinencephalic structures including piriform cortex

behavior/neurological

abnormal learning/memory/conditioning ( J:44679 )

• showed residual spatial learning ability

increased aggression ( J:44679 )

• difficulty in handling from birth, exhibiting hyperexcitability and very aggressive behavior

• all male mutants mutilated or killed their littermates, although they were 30-50% smaller

• 45% of the females examined were also aggressive

abnormal maternal nurturing ( J:44679 )

♀ • failed to care for their offspring