Phenotypes associated with this allele

• Allele Symbol: pogo
• Allele Name: pogostick
• Allele ID: MGI:2148487
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	pogo/pogo	KJR/MsKist-pogo	MGI:3623254

Genotype
MGI:3623254

hm1

• Allelic Composition: pogo/pogo
• Genetic Background: KJR/MsKist-pogo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Photomicrographs of Purkinje cells of 40 day old pogo/pogo and +/+ mouse

behavior/neurological

ataxia ( J:68106 )

• affected mice show ataxia characterized by a wobbly gait and tendency to fall over

impaired coordination ( J:68106 )

• in a still-rod test, wild-type mice remain on the rod for 2 minutes, but mutants fall within 7 seconds

abnormal posture ( J:68106 )

• when placed in a glass beaker, 2 of 6 mutants are unable to rear, and when the remaining 4 rear, their haunches touch the surface of the beaker due to the abnormally large distance between the hindpaws during rearing (53.75 mm versus 25.71 mm in wild type

nervous system

abnormal Purkinje cell dendrite morphology ( J:67170 , J:68106 )

• dendrites showed abnormal enlargements and megadendrites with vacuolization in the cytoplasm are frequently observed; dendritic arbors are reduced in density and focal axonal swellings are frequently observed often as axons cross the granular layer (J:67170)

• dendrites of Purkinje cells in mutants have larger cross-sectional areas than wild-type (J:68106)

abnormal cerebellum vermis morphology ( J:108023 )

• mutant mice display a loss of Purkinje cells throughout the vermis

homeostasis/metabolism

decreased glutamic acid level ( J:108023 )

• mutants have significantly lower concentrations of glutamate in the cerebellum