Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Bbd mutation
(0 available);
any
Gdnf mutation
(18 available)
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mortality/aging
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• die within the first day of life
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renal/urinary system
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• in mutant mice that do develop a ureteric bud, the bud never invades the metanepric mesenchyme
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• many mutant mice do not develop the ureteric bud
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digestive/alimentary system
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• dilated duodenum, however the gonads and adrenal glands develop normally
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nervous system
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• no enteric neurons detected in the lower esophagus, stomach, small intestine or colon in newborns
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• 20% reduction in volume of superior cervical ganglion neurons
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• 21% decrease in motor neuron number in the trigeminal motor nucleus
• 31% decrease in motor neuron number in the L4-L5 levels of the spinal cord, however no differences in facial motor neurons are observed
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Allelic
Composition |
Gdnftm1Bbd/Gdnf+
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Genetic
Background |
involves: 129S1/Sv * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Bbd mutation
(0 available);
any
Gdnf mutation
(18 available)
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renal/urinary system
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• animals show renal hypoplasia at birth
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• 14% of mice have no kidneys
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• 18% of mice exhibit one kidney
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• either unilateral or a complete lack of ureteric bud development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation
(0 available);
any
Egr3 mutation
(15 available)
Gdnftm1.1Neas mutation
(1 available);
any
Gdnf mutation
(18 available)
Gdnftm1Bbd mutation
(0 available);
any
Gdnf mutation
(18 available)
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nervous system
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• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
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• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit selective loss of gamma-motor neurons compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Bbd mutation
(0 available);
any
Gdnf mutation
(18 available)
Gdnftm1Jlob mutation
(0 available);
any
Gdnf mutation
(18 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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nervous system
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• tamoxifen treatment leads to the death of catecholaminergic neurons in the brain
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• 210 days after tamoxifen treatment, there is a substantial lose (about 50%) of tyrosine hydroxylase positive neurons in the substantia nigra adult mice
• there is also a drop in the total number of neurons in the substantia nigra after tamoxifen treatment
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• 210 days after tamoxifen treatment, there is a substantial lose (about 2.5-fold) of tyrosine hydroxylase positive neurons in the ventral tegmentum of adult mice
• there is also a drop in the total number of neurons in the ventral tegmentum after tamoxifen treatment
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• neurons are diminished in the locus ceruleus 210 days after tamoxifen treatment
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• fiber density of tyrosine hydroxylase positive neurons are diminished 210 days after tamoxifen treatment
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• fiber density of tyrosine hydroxylase positive neurons are diminished 210 days after tamoxifen treatment
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behavior/neurological
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• 100 days after tamoxifen injection, mice have reduced activity in open field tests with about 25% less activity
• resting time of mice in open field tests increases significantly 100 days after tamoxifen treatment
• this hypoactivity worsens with the passage of time
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cardiovascular system
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• tyrosine hydroxylase positive neurons are diminished by more than half 210 days after tamoxifen-treatment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Bbd mutation
(0 available);
any
Gdnf mutation
(18 available)
Spry1tm1.1Jdli mutation
(0 available);
any
Spry1 mutation
(15 available)
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renal/urinary system
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N |
• at E19.5, double heterozygous animals show full rescue of the renal hypoplasia seen in Gdnftm1Bbd heterozygotes
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Analysis Tools