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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Emx1tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:2136349
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2tm1Sia 		involves: C57BL/6 * CBA MGI:2182344
cx2
 		Emx1tm1Sia/Emx1tm1Sia
Otx2tm1Sia/Otx2+ 		involves: C57BL/6 * CBA MGI:3580107
cx3
 		Emx1tm1Sia/Emx1tm1Sia
Rr103tm3Sia/Rr103tm3Sia 		involves: C57BL/6 * CBA MGI:4830714
cx4
 		Emx1tm1Sia/Emx1tm1Sia
Rr103tm3.1Sia/Rr103tm3.1Sia 		involves: C57BL/6 * CBA MGI:4830717
cx5
 		Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2+ 		involves: C57BL/6 * CBA MGI:4830718
cx6
 		Emx1tm1Sia/Emx1tm1Sia
Otx1tm1Sia/Otx1tm1Sia 		Not Specified MGI:3580108


Genotype
MGI:2182344
cx1
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2tm1Sia
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (30 available)
Emx2tm1Sia mutation (1 available); any Emx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal pallium development ( J:163926 )
• mice exhibit a remarkable loss of the medial pallium compared with wild-type mice




Genotype
MGI:3580107
cx2
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Otx2tm1Sia/Otx2+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (30 available)
Otx2tm1Sia mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:98539 )
N
• do not exhibit defects in the forebrain at E12.5




Genotype
MGI:4830714
cx3
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Rr103tm3Sia/Rr103tm3Sia
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (30 available)
Rr103tm3Sia mutation (0 available); any Rr103 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal pallium development ( J:163926 )
• mice exhibit a moderate loss of the medial pallium compared with wild-type mice
abnormal cerebral cortex morphology ( J:163926 )
• mice exhibit moderately defective cortical lamination compared with wild-type mice
• however, mice exhibit normal ganglionic eminences




Genotype
MGI:4830717
cx4
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Rr103tm3.1Sia/Rr103tm3.1Sia
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (30 available)
Rr103tm3.1Sia mutation (0 available); any Rr103 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal pallium development ( J:163926 )
• mice exhibit a moderate loss of the medial pallium compared with wild-type mice
abnormal cerebral cortex morphology ( J:163926 )
• mice exhibit moderately defective cortical lamination compared with wild-type mice
• however, mice exhibit normal ganglionic eminences




Genotype
MGI:4830718
cx5
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Emx2tm1Sia/Emx2+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (30 available)
Emx2tm1Sia mutation (1 available); any Emx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:163926 )
• interneurons are scarce in the cortex due to a failure of their tangential migration compared to in wild-type mice
abnormal embryonic/fetal subventricular zone morphology ( J:163926 )
• failure of interneurons to migrate into the cortex leads to hyperplasia of ganglionic eminences compared to in wild-type mice




Genotype
MGI:3580108
cx6
Allelic
Composition		 Emx1tm1Sia/Emx1tm1Sia
Otx1tm1Sia/Otx1tm1Sia
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1Sia mutation (1 available); any Emx1 mutation (30 available)
Otx1tm1Sia mutation (1 available); any Otx1 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:98539 )
N
• do not exhibit defects in the forebrain at E12.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory