All Phenotypes Kras<tm3Tyj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kras^tm3Tyj
targeted mutation 3, Tyler Jacks
MGI:2136169

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kras^tm3Tyj/Kras^tm3Tyj	involves: 129S4/SvJae	MGI:3769019
ht2	Kras^tm3Tyj/Kras⁺	involves: 129S4/SvJae	MGI:3770517
ht3	Kras^tm3Tyj/Kras⁺	involves: 129S4/SvJae * C57BL/6	MGI:3770516
cx4	Ccne1^tm1Jro/? Kras^tm3Tyj/?	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3586557
cx5	Eif4e^{Gt(RRO036)Byg}/Eif4e⁺ Kras^tm3Tyj/Kras⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5708384
cx6	Kras^tm3Tyj/Kras⁺ Pik3ca^tm1Jdo/Pik3ca^tm1Jdo	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3716661
cx7	Kras^tm3Tyj/Kras⁺ Tg(CAG-Mir21,-EGFP)#Eno/0	involves: 129S4/SvJae * C3H * C57BL/6	MGI:5317786
cx8	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs Kras^tm3Tyj/Kras⁺	involves: 129S4/SvJae * C57BL/6	MGI:3770618
cx9	Dmtf1^tm1Cjs/Dmtf1⁺ Kras^tm3Tyj/Kras⁺	involves: 129S4/SvJae * C57BL/6	MGI:3770617
cx10	Kras^tm3Tyj/Kras^tm3Tyj Mir301^tm1Yoli/Mir301^tm1Yoli	involves: 129S4/SvJae * C57BL/6J	MGI:5823077
cx11	Slc25a11^em1Syki/Slc25a11⁺ Kras^tm3Tyj/Kras⁺	involves: 129S * C57BL/6	MGI:6469642
cx12	Kras^tm3Tyj/Kras⁺ Mir21a^tm1.1Eno/Mir21a^tm1.1Eno	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:5317787

Allelic Composition	Kras^tm3Tyj/Kras^tm3Tyj
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:237900 )

• 32.3% incidence of thymic lymphomas by 18 weeks of age

integument

increased skin papilloma incidence ( J:237900 )

• 17.6% incidence of skin papillomas by 18 weeks of age

mortality/aging

premature death ( J:237900 )

• survival rate is 165+/-64 days

neoplasm

increased T cell derived lymphoma incidence ( J:237900 )

• 32.3% incidence of thymic lymphomas by 18 weeks of age

increased skin papilloma incidence ( J:237900 )

• 17.6% incidence of skin papillomas by 18 weeks of age

increased lung tumor incidence ( J:237900 )

• mice develop lung tumors at 18 weeks

respiratory system

increased lung tumor incidence ( J:237900 )

• mice develop lung tumors at 18 weeks

Allelic Composition	Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:68981 )

• Background Sensitivity: mean age at death is ~250 days on pure 129/Sv background compared to 200 days on mixed background

neoplasm

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

increased lung tumor incidence ( J:119477 )

• 100% of mice examined at 3-4 months of age have developed lung tumors

integument

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

respiratory system

increased lung tumor incidence ( J:119477 )

• 100% of mice examined at 3-4 months of age have developed lung tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:68981

Allelic Composition	Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:68981 )

• Background Sensitivity: mean age at death is ~200 days

neoplasm

increased tumor incidence ( J:68981 )

• all animals at time of death/sacrifice have extensive tumor burden

• mice display a more rapid tumor phenotype than Kras^tm2Tyj heterozygotes

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~40% of animals)

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma

increased lung tumor incidence ( J:68981 )

• 100% of animals show multifocal tumors at time of death/sacrifice

• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death

• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium

• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs

increased lung adenoma incidence ( J:68981 )

• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation

increased lung adenocarcinoma incidence ( J:68981 )

• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:68981 )

• mutants have multiple aberrant crypt foci (ACF) of the colon

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:68981 )

• mutants have multiple aberrant crypt foci (ACF) of the colon

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~40% of animals)

integument

increased skin papilloma incidence ( J:68981 )

respiratory system

increased lung tumor incidence ( J:68981 )

• 100% of animals show multifocal tumors at time of death/sacrifice

• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death

• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium

• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs

increased lung adenoma incidence ( J:68981 )

• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation

increased lung adenocarcinoma incidence ( J:68981 )

• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:68981

Allelic Composition	Ccne1^tm1Jro/? Kras^tm3Tyj/?
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1^tm1Jro mutation (0 available); any Ccne1 mutation (23 available)
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99695 )

• mean survival is reduced to 160 days compared to 260 days for mice homozygous for Kras alone

cellular

chromosome breakage ( J:99695 )

• 2 of 6 tumors from double mutants display significant gains or losses of whole chromosomes while no gains or losses of whole chromosomes are seen in Kras homozygotes

Allelic Composition	Eif4e^{Gt(RRO036)Byg}/Eif4e⁺ Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4e^{Gt(RRO036)Byg} mutation (0 available); any Eif4e mutation (42 available)
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:224214 )

• smaller tumors of mice treated with piperlongumine than in Kras^tm3Tyj heterozygotes

decreased lung tumor incidence ( J:224214 )

• fewer tumors by 12 weeks with a more than 2-fold reduction in tumor burden compared with Kras^tm3Tyj heterozygotes

cellular

increased cellular sensitivity to oxidative stress ( J:224214 )

• in tumors of mice treated with piperlongumine

oxidative stress ( J:224214 )

• increased compared with Kras^tm3Tyj heterozygotes

Allelic Composition	Kras^tm3Tyj/Kras⁺ Pik3ca^tm1Jdo/Pik3ca^tm1Jdo
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)
Pik3ca^tm1Jdo mutation (1 available); any Pik3ca mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of induced tumors ( J:122866 )

• zero to two visible tumors are found compared to forty or so tumors in Kras^tm3Tyj mice

• apoptotic rates in small lesions are increased compared to in Kras^tm3Tyj mice

decreased lung tumor incidence ( J:122866 )

• one mouse did not show any evidence of lung tumor formation up to 6 months of age

Allelic Composition	Kras^tm3Tyj/Kras⁺ Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)
Tg(CAG-Mir21,-EGFP)#Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:164198 )

• mice exhibit premature death compared with wild-type mice

• however, mice exhibit the same mortality as Kras^tm3Tyj heterozygotes

neoplasm

increased tumor growth/size ( J:164198 )

• increased proliferation of tumor cells compared with tumor cells from Kras^tm3Tyj heterozygotes

increased lung tumor incidence ( J:164198 )

• at 18 weeks compared with Kras^tm3Tyj heterozygotes

• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Kras^tm3Tyj heterozygotes

increased lung non-small cell carcinoma incidence ( J:164198 )

decreased tumor incidence ( J:164198 )

• of thymic tumors compared with Kras^tm3Tyj heterozygotes

respiratory system

increased lung tumor incidence ( J:164198 )

• at 18 weeks compared with Kras^tm3Tyj heterozygotes

• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Kras^tm3Tyj heterozygotes

increased lung non-small cell carcinoma incidence ( J:164198 )

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1^tm1Cjs mutation (3 available); any Dmtf1 mutation (83 available)
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras^+/-, Dmtf1-sufficient mice

neoplasm

increased T cell derived lymphoma incidence ( J:126002 )

• ~20% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

increased lung tumor incidence ( J:126002 )

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126002 )

• ~20% of mice develop thymic lymphomas

respiratory system

increased lung tumor incidence ( J:126002 )

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1⁺ Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras^+/-, Dmtf1-sufficient mice

neoplasm

increased T cell derived lymphoma incidence ( J:126002 )

• ~35% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

abnormal metastatic potential ( J:126002 )

• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in Kras^LA+/-, Dmtf1-sufficient mice

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126002 )

• ~35% of mice develop thymic lymphomas

respiratory system

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

Allelic Composition	Kras^tm3Tyj/Kras^tm3Tyj Mir301^tm1Yoli/Mir301^tm1Yoli
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)
Mir301^tm1Yoli mutation (1 available); any Mir301 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased skin tumor incidence ( J:237900 )

• decreased incidence of skin papillomas (7.1% vs 17.6%) as compared to mice homozygous for Kras^tm3Tyj

mortality/aging

premature death ( J:237900 )

• increased survival rates (approx 262 days vs 166 days) as compared to mice homozygous for Kras^tm3Tyj

neoplasm

decreased tumor growth/size ( J:237900 )

• tumors are smaller in size when compared to tumors from mice homozygous for Kras^tm3Tyj

decreased tumor incidence ( J:237900 )

decreased skin tumor incidence ( J:237900 )

• decreased incidence of skin papillomas (7.1% vs 17.6%) as compared to mice homozygous for Kras^tm3Tyj

decreased lymphoma incidence ( J:237900 )

• decreased incidence of thymic lymphomas (21.4% vs 32.3%) as compared to mice homozygous for Kras^tm3Tyj

decreased lung tumor incidence ( J:237900 )

• decrease in number of lung tumors at 18 weeks as compared to mice homozygous for Kras^tm3Tyj although all mice develop lung tumor

• decreased incidence of thymic lymphomas (21.4% vs 32.3%) and skin papillomas (7.1% vs 17.6%)

Allelic Composition	Slc25a11^em1Syki/Slc25a11⁺ Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)
Slc25a11^em1Syki mutation (0 available); any Slc25a11 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased lung tumor incidence ( J:294965 )

• 60% reduction of number of tumor nodes at age 12 weeks

• 54% reduction in tumor area at age 12 weeks

Allelic Composition	Kras^tm3Tyj/Kras⁺ Mir21a^tm1.1Eno/Mir21a^tm1.1Eno
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)
Mir21a^tm1.1Eno mutation (0 available); any Mir21a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:164198 )

N	• unlike Kras^tm3Tyj heterozygotes, mice do not develop skin papillomas or lung adenomcarcinomas

increased T cell derived lymphoma incidence ( J:164198 )

• fewer than in Kras^tm3Tyj heterozygotes

decreased tumor growth/size ( J:164198 )

• mice exhibit decreased total tumor area relative to lung area compared with Kras^tm3Tyj heterozygotes

• however, tumor cell proliferation is the same as in Kras^tm3Tyj heterozygotes

increased lung adenoma incidence ( J:164198 )

• mice develop fewer lung adenoma than in Kras^tm3Tyj heterozygotes

decreased tumor incidence ( J:164198 )

• mice develop fewer thymic lymphoma, lung hyperplasia and lung adenomas than in Kras^tm3Tyj heterozygotes

decreased lung tumor incidence ( J:164198 )

• fewer lung adenoma than in Kras^tm3Tyj heterozygotes

respiratory system

increased lung adenoma incidence ( J:164198 )

• mice develop fewer lung adenoma than in Kras^tm3Tyj heterozygotes

lung epithelium hyperplasia ( J:164198 )

• mice develop fewer lung hyperplasia than in Kras^tm3Tyj heterozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:164198 )

• fewer than in Kras^tm3Tyj heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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