Analysis Tools
renal/urinary system
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• in vitro, mesangial cells exhibit reduced proliferation and migration toward PDGF-BB
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• mutants injected with anti-GBM antibody to induce experimental glomerulonephritis develop proteinuria and glomerular and tubulointerstitial renal injury to a similar extent as controls, however they consistently have fewer cells in the glomeruli, corresponding to increased mesangial cell loss, and show an increase in capillary thrombi
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• in vitro, mesangial cells exhibit reduced to negligible proliferation when stimulated with PDGF-BB compared to wild-type
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cellular
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• in vitro, mesangial cells exhibit reduced proliferation and migration toward PDGF-BB
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• in vitro, MEFs exhibit reduced to negligible proliferation when stimulated with PDGF-BB compared to wild-type
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• in vitro, mesangial cells exhibit reduced to negligible proliferation when stimulated with PDGF-BB compared to wild-type
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cardiovascular system
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• arterioles, capillaries, and glomeruli of both the developing and adult kidney and brain appear normal with no apparent hemorrhages
• the aorta and renal arteries display a normal smooth muscle cell layer
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