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Allele Symbol Allele Name Allele ID |
Dcctm1Wbg targeted mutation 1, Robert A Weinberg MGI:1934924 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no trochlear nerve abnormalities are detected at E11.5 and diaphragm innervation is similar to wild-type at E18.5
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• at E13.5 ectopic motor neurons are found to have migrated out of the ventral horn and into the root, with 42% of roots having ectopic neurons and an average of 1.7 cells per root
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice died within 24 hours of birth
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• mice appeared unable to suckle
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• mice exhibited labored respirations
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• some misrouting of commissural axons that projected into the ventral spinal cord
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• absent hippocampal commissure
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• absence of pontine nuclei from the hindbrain
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• reduction in the number of commissural axons with the dorsal spinal cord of mice examined at E9.5-E11.5
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• some misrouting of commissural axons that projected into the ventral spinal cord
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypopigmented streaks in E15-E16 embryos
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• small optic discs in E15-E16 embryos; optic nerve hypoplasia
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• retinal ganglion cells failed to exit the optic nerve and were misrouted to other regions of the eye
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• hypopigmented streaks in E15-E16 embryos
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• small optic discs in E15-E16 embryos; optic nerve hypoplasia
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• retinal ganglion cells failed to exit the optic nerve and were misrouted to other regions of the eye
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus
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• absent hippocampal commissure
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• no axons cross the midline at the pyramidal decussation
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• absent from the dorsal funiculus
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• axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a few axons fail to cross the midline at the pyramidal decussation and instead extend into the ventral funiculus of the cervical spinal cord
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• a few axons fail to cross the midline at the pyramidal decussation and instead extend into the ventral funiculus of the cervical spinal cord
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus
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• some axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygosity for the Dcc allele did not affect the polyp initiation or average size or morphology of the adenomas that occur in the ApcMin heterozygous mice
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• heterozygosity for the Dcc allele did not affect the polyp initiation or average size or morphology of the adenomas that occur in the ApcMin heterozygous mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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