Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation
(3 available);
any
C5ar1 mutation
(27 available)
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vision/eye
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• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age
• however, no other component of the dc-ERG is different and mice show normal ERG a-waves and b-waves even at 12 months of age
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation
(3 available);
any
C5ar1 mutation
(27 available)
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mortality/aging
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• mutants challenged with Psuedomonas aeruginosa succumb in the second day after challenge while no wild-type mice die
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immune system
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• when peritoneal inflammation is induced with glycogen in mutants, a decreased number of neutrophils is elicited
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• after injection of chicken egg albumin in the tail and administration of antibodies to egg albumin intratracheally, the null mice exhibit almost complete protection from inflammatory response upon examination of lung tissue
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• mutants are unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite an increase in neutrophil influx, and succumb to pneumonia
• however, mutants are able to clear the bacteria when challenged intraperitoneally
• mutants challenged with a sublethal dose of Pseudomonas become superinfected with secondary bacterial strains
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hematopoietic system
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• when peritoneal inflammation is induced with glycogen in mutants, a decreased number of neutrophils is elicited
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation
(3 available);
any
C5ar1 mutation
(27 available)
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skeleton
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• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
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immune system
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• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
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• Il-6 production after vitamin D3 stimulation is significantly reduced
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hematopoietic system
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• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
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homeostasis/metabolism
vision/eye
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• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice
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• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
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• density of horizontal cells is decreased
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• the normal structure of the outer segment discs is lost at 6 months of age
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• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months
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• the inner nuclear layer is thinner at 3 and 14 months of age
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• outer nuclear layer thinning is seen at older ages
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• the outer nuclear layer is disorganized at 3 months of age
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• mice show progressive retinal cell loss
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• the fast oscillation is reduced at 6 months of age
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show a more severe reduction in ERG amplitude, however this phenotype is not related to immune responses as IL17-producting cells are diminished
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• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age
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• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age
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• the amplitude of the c-wave is reduced at 6 months of age
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homeostasis/metabolism
cellular
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• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice
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nervous system
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• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
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• density of horizontal cells is decreased
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• the normal structure of the outer segment discs is lost at 6 months of age
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pigmentation
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• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months
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Analysis Tools