Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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muscle
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• at E10.75 fewer hypaxial muscle progenitor cells reach the floor of the first branchial arch
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• the intrinsic tongue muscle is smaller but present
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• limb muscle size is reduced and in the proximal portion of the lower forelimb, particular extensor muscles of dorsal limb are reduced in size
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digestive/alimentary system
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• the intrinsic tongue muscle is smaller but present
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craniofacial
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• the intrinsic tongue muscle is smaller but present
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cellular
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• at E10.75 fewer hypaxial muscle progenitor cells reach the floor of the first branchial arch
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growth/size/body
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• the intrinsic tongue muscle is smaller but present
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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mortality/aging
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• from E13.5 to E18.5 the proportion of viable homozygous mice decreases with none born alive
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embryo
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• at E13.5, the extracellular matrix around fetal blood vessels is fragmented and fetal blood cells are occasionally seen infiltrating the trophoblast layer
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• at E13.5, the labyrinth layer is disorganized, reduced in thickness and contains less blood; however the spongiotrophoblast layer is similar to wild-type
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muscle
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• at E10.25, fewer progenitor cells have delaminated from the occipitally located somites and the precursor stream headed for the floor of the branchial arches contains fewer cells and does not extend as far distally as in wild-type
• at E10.25, fewer precursor cells are found in the forelimb bud with the dorsal forelimb most strongly affected
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• at E13.5 the diaphragm muscle is reduced in size; however the internal tongue muscle appears normal
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• at E14.5 in the proximal lower forelimb the extensor muscle groups are either absent or very small while the flexor groups are present and in the distal lower forelimb only traces of muscle cells are found
• at E14.5 in the hindlimb some muscle groups are present but reduced in size and distal muscles are more severely affected
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liver/biliary system
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• at E14.5, the liver to body weight ratio is significantly reduced (0.05 versus 0.088 in wild-type)
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growth/size/body
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• from E13.5 to E18.5 surviving embryos show a gradual delay in growth and development
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integument
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• at E14.5 follicle development appears normal but by E17.5 hair follicle outgrowth is retarded and the number of follicles is reduced possibly reflect the reduction in total body size
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• at E17.5, keratinization is reduced
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cardiovascular system
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• at E13.5, the extracellular matrix around fetal blood vessels is fragmented and fetal blood cells are occasionally seen infiltrating the trophoblast layer
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cellular
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• at E10.25, fewer progenitor cells have delaminated from the occipitally located somites and the precursor stream headed for the floor of the branchial arches contains fewer cells and does not extend as far distally as in wild-type
• at E10.25, fewer precursor cells are found in the forelimb bud with the dorsal forelimb most strongly affected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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Cleft palate in Gab1tm3Wbm/Gab1tm3Wbm, Gab1tm2Wbm/Gab1tm2Wbm, Gab1tm1Wbm/Gab1tm1Wbm and Gab1tm3Wbm/Gab1tm3Wbm Mettm1Cbm/Met+ mice, but not in Gab1tm4Wbm/Gab1tm4Wbm mice
craniofacial
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• at E16, many mice have an open secondary palate
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muscle
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• extensor muscles are missing and muscles reach less far distally
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digestive/alimentary system
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• at E16, many mice have an open secondary palate
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growth/size/body
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• at E16, many mice have an open secondary palate
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Allelic
Composition |
Gab1tm1Wbm/Gab1+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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mortality/aging
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• about 5% of heterozygotes develop after spasms 2-3 months of age and die
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behavior/neurological
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• about 5% of heterozygotes develop after spasms 2-3 months of age and die
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Qma mutation
(1 available);
any
Cxcr4 mutation
(40 available)
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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muscle
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• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• at E10.75, the number of muscle cells (MyoD+) is further reduced and the number of apoptotic cells is increased in the dorsal and ventral limbs compared to Gab single homozygotes
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• limb muscle size is reduced and in the proximal portion of the lower forelimb, particular extensor muscles of dorsal limb are absent and the flexor muscles are reduced in size compared to Gab1 single homozygotes
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digestive/alimentary system
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• the overall size of the tongue is very small
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craniofacial
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• the overall size of the tongue is very small
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cellular
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• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch
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growth/size/body
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• the overall size of the tongue is very small
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
Mettm1Cbm mutation
(0 available);
any
Met mutation
(82 available)
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muscle
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• at E14.5, muscles are virtually absent from all lower limbs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Mak mutation
(1 available);
any
Cd44 mutation
(67 available)
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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mortality/aging
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• shortly after birth, 60% of the animals die
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• shortly after birth, 60% of the animals die
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Analysis Tools