Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Qma mutation
(1 available);
any
Cxcr4 mutation
(40 available)
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muscle
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• at E10.75 fewer hypaxial muscle progenitor cells reach the floor of the first branchial arch
• at E10.75, fewer progenitor cells are seen in the dorsal limb and this reduction is more pronounced distally (35%) than proximally (25%)
• however, no significant change in proliferation of muscle progenitors is seen
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• at E10.75, the number of muscle cells (MyoD+) is reduced in the dorsal limb and this reduction is more pronounced distally than proximally; however at E13.5 the size and distribution of the muscle groups is not significantly different from control
• increased apoptosis is seen in the proximal domain of the dorsal limb
• however, no significant difference is seen in the size of the tongue muscle
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cellular
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• at E10.75 fewer hypaxial muscle progenitor cells reach the floor of the first branchial arch
• at E10.75, fewer progenitor cells are seen in the dorsal limb and this reduction is more pronounced distally (35%) than proximally (25%)
• however, no significant change in proliferation of muscle progenitors is seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Qma mutation
(1 available);
any
Cxcr4 mutation
(40 available)
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mortality/aging
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• about 1/3 of mice are dead at E18.5
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nervous system
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• at E18.5, the cerebellum is disorganized with a highly distorted architecture and chromophillic cell clumps in the analage
• chromophillic clusters mostly contain early granule cell progenitors that are surrounded by Purkinje cells
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• at E18.5, the external granule cell layer is attenuated and irregular
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hematopoietic system
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• at E18.5, the B220+/CD43+ pro-B cell population is severely reduced in the fetal liver (0.2% versus 7.0% in wild-type littermates); however T cell populations in the thymus are normal
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• at E18.5 in the fetal liver, myeloid cells are reduced to 25% of wild-type, myelopoiesis is reduced and a marked erythroid predominance is seen
• at E18.5, a marked reduction in myeloid cells is also seen in the spleen and myeloid cells are virtually absent from the bone marrow
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• at E15.5, bone marrow is hypocellular and composed mostly of stromal cells and osteoblasts with a severe reduction in hematopoiesis
• at E18.5, hematopoiesis is still reduced but cellularity is similar to wild-type; however myeloid cells are virtually absent
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growth/size/body
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• viable homozygotes are smaller than littermates
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renal/urinary system
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• prominent interstitial hemorrhage
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respiratory system
immune system
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• at E18.5, the B220+/CD43+ pro-B cell population is severely reduced in the fetal liver (0.2% versus 7.0% in wild-type littermates); however T cell populations in the thymus are normal
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• at E18.5 in the fetal liver, myeloid cells are reduced to 25% of wild-type, myelopoiesis is reduced and a marked erythroid predominance is seen
• at E18.5, a marked reduction in myeloid cells is also seen in the spleen and myeloid cells are virtually absent from the bone marrow
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cardiovascular system
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• prominent interstitial hemorrhage
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Qma mutation
(1 available);
any
Cxcr4 mutation
(40 available)
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nervous system
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• abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV
• decreased survival from gp120 from a CCR5 preferring isolate of HIV
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immune system
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• decreased survival from gp120 from a CCR5 preferring isolate of HIV
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• abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV
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mortality/aging
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• decreased survival from gp120 from a CCR5 preferring isolate of HIV
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Qma mutation
(1 available);
any
Cxcr4 mutation
(40 available)
Gab1tm1Wbm mutation
(0 available);
any
Gab1 mutation
(78 available)
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muscle
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• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• at E10.75, the number of muscle cells (MyoD+) is further reduced and the number of apoptotic cells is increased in the dorsal and ventral limbs compared to Gab single homozygotes
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• limb muscle size is reduced and in the proximal portion of the lower forelimb, particular extensor muscles of dorsal limb are absent and the flexor muscles are reduced in size compared to Gab1 single homozygotes
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digestive/alimentary system
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• the overall size of the tongue is very small
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craniofacial
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• the overall size of the tongue is very small
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cellular
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• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch
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growth/size/body
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• only a fragment of the intrinsic muscle is present in the proximal tongue
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• the overall size of the tongue is very small
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nervous system
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• abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV
• abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV
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immune system
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• abrogated neurotoxicity to gp120 from a CCR5 preferring isolate of HIV
• abrogated neurotoxicity to gp120 from a CCR4 preferring isolate of HIV
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Analysis Tools