Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation
(1 available);
any
Trpv1 mutation
(59 available)
|
|
|
behavior/neurological
|
N |
• mice exhibit normal general locomotion and pain threshold
|
|
|
• mice exhibit less freezing after stress sensitization compared with wild-type mice
|
|
|
• mice exhibit less conditioned freezing in response to a context compared with wild-type mice
|
|
|
• mice exhibit less conditioned freezing in response to an auditory cue compared with wild-type mice
|
|
|
• in a light-dark test, mice spend more time exploring the light compartment than wild-type mice
• in an elevated plus maze, mice spend more time in open arms and make more entries into open arms compared with wild-type mice
|
renal/urinary system
|
|
• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion
|
|
|
• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary albumin excretion
|
|
|
• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice
• however, DEXA treatment prevents kidney inflammation
|
|
|
• DOCA-salt-treated mice exhibit a greater glomerulosclerosis than similarly treated wild-type mice
• however, DEXA treatment reduces glomerulosclerosis
|
|
|
• DOCA-salt-treated mice exhibit more severe renal tubular injury in the renal cortex and outer medulla than similarly treated wild-type mice
• however, DEXA treatment reduces renal tubule damage
|
nervous system
|
N |
• mice exhibit normal paired-pulse facilitation, auditory brainstem responses, and distortion-product otoacoustic emissions
|
|
|
• following high frequency stimulation, long term potentiation is weaker than in similarly treated wild-type mice
|
homeostasis/metabolism
immune system
|
|
• DOCA-salt-treated mice exhibit increased MCP-1 protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
|
|
|
• DOCA-salt-treated mice exhibit increased IL6 protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
|
|
|
• DOCA-salt-treated mice exhibit increased TNFalpha protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
|
|
|
• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice
• however, DEXA treatment prevents kidney inflammation
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation
(1 available);
any
Trpv1 mutation
(59 available)
|
|
|
homeostasis/metabolism
nervous system
|
|
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice
• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice
|
|
|
• in response to hyperosmotic stimulation, supraoptic nucleus neurons fail to generate an increase in membrane conductance and depolarizing potentials unlike similarly treated wild-type cells
|
|
|
• impulse frequency of action potentials in colon sensory neurons at 45 degrees Celsius is lower than in similarly treated wild-type cells
• colon sensory neurons fail to exhibit a sustained-type current response to protons unlike similarly treated wild-type cells
• colon sensory neurons fail to exhibit a temperature sensitive response or 5-HT effect unlike similarly treated wild-type cells
|
|
|
• temperatures below 50 degrees Celsius generate few action potentials in colon sensory neurons unlike in similarly treated wild-type cells
|
|
|
• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice
• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice
|
cardiovascular system
|
|
• after ischemia and during reperfusion
|
|
|
• after ischemia and during reperfusion
|
|
|
• after ischemia and during reperfusion
|
|
|
• after ischemia and during reperfusion, mice exhibit impaired recovery with lower left ventricular end diastolic pressure and higher left ventricle developed pressure and coronary flow compared with similarly treated wild-type mice
• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice
|
growth/size/body
|
|
• mice fed a high fat diet and treated with capsaicin fail to exhibit a decrease in body weight compared with similarly treated wild-type mice
|
behavior/neurological
|
N |
• mice exhibit normal tactile hypersensitivity and allodynia following spinal nerve ligation
(J:132700)
• mice exhibit normal water consumption and ethanol-induced conditioned taste aversion
(J:153529)
|
|
|
• mice exhibit greater preference for ethanol than wild type mice in a two-bottle test
|
|
|
• mice consume more ethanol than wild-type mice in a two-bottle test
|
|
|
• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice
• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice
• however, mice exhibit normal acute ethanol withdrawal severity
|
|
|
• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice
|
|
|
• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice
|
|
|
• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice
|
|
|
• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice
|
taste/olfaction
|
|
• at high concentrations, mice exhibit a less aversion to FeSO4 than wild-type mice
• mice exhibit less aversion to 10 mM CuSO4 than wild-type mice
• however, aversion to ZnSO4 is normal
|
integument
|
|
• mice exhibit delays in the onset of catagen and telogen compared with wild-type mice
• however, follicle cycling is normal once initiated
|
|
|
• at P19, mice exhibit a retardation in catagen compared with wild-type mice
|
|
|
• slightly retarded at P25
|
cellular
|
|
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice
• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation
(1 available);
any
Trpv1 mutation
(59 available)
|
|
|
behavior/neurological
|
|
• following an injection of a hypertonic solution, mice drink water less than similarly treated wild-type mice
|
|
|
• reduced thermal hypersensitvitiy following inflammation
|
|
|
• mutants show normal responses to noxious mechanical stimuli but exhibit no vanilloid-evoked pain behavior, are impaired in the detection of painful heat, and show little thermal hypersensitivity in the setting of inflammation
(J:61534)
• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type
(J:197482)
|
|
|
• mutants exhibit no vanilloid (capsaicin and resiniferatoxin) evoked pain behavior: no behavioral response and less swelling with vanilloid injection into plantar skin of hind paw, no aversive response to drinking capsaicin supplemented water, and no reduction in temperature in response to capsaicin injection
|
|
|
• mutants exhibit reduced sensitivity to painful heat in behavioral tests, with longer mean withdrawal latencies in the tail immersion test at temperatures greater than 48 degrees Celcius and longer response latencies at temperatures greater than 50 degrees Celcius in the hot plate assay
(J:61534)
• mutants treated with mustard oil show little or no change in hot plate latency
(J:61534)
• mice show increased latencies (impaired nociceptive response) in tail-immersion and hot plate paradigms
(J:197482)
|
nervous system
|
|
• in response to osmotic stimulation, organum vasculosum lamina terminalis neurons fail to exhibit changes in membrane potential or conductance unlike similarly treated wild-type cells
|
|
|
• in response to osmotic stimulation, organum vasculosum lamina terminalis neurons fail to exhibit an increase in action potential firing compared with similarly treated wild-type cells
|
|
|
• sensory neurons and primary afferent fibers show a reduction in proton (pH5) sensitivity in vitro (acid-evoked nociception)
• incidence of noxious heat-evoked currents of the moderate-threshold (greater than 43 degrees Celcius) class is reduced in cultured sensory neurons or sensory nerve fibers but high-threshold responses remain intact
• vanilloid compounds, capsaicin and resiniferatoxin, are completely inactive on neurons from mutants, showing no increases in calcium or inward currents
• mutants treated with mustard oil show little or no chmutants treated with mustard oil show no enhancement of thermally evoked responses in wide dynamic range neurons of the lumbar dorsal horn
|
adipose tissue
|
|
• when fed a high fat diet compared with similarly treated wild-type mice
|
|
|
• when fed a high fat diet compared with similarly treated wild-type mice
|
|
|
• when fed a high fat diet compared with similarly treated wild-type mice
|
growth/size/body
|
|
• when fed a high fat diet compared with similarly treated wild-type mice
|
homeostasis/metabolism
liver/biliary system
|
|
• when fed a high fat diet, mice exhibit reduced hepatic fat content and reduced lipid droplets compared with similarly treated wild-type mice
|
integument
|
|
• when fed a high fat diet compared with similarly treated wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation
(1 available);
any
Trpv1 mutation
(59 available)
|
|
|
homeostasis/metabolism
renal/urinary system
|
|
• increased frequency of non-voiding contractions
• the frequency of and strength voiding contractions were similar those of wild-type littermates
|
neoplasm
|
|
• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks
• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous
|
immune system
|
|
• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Mrgpra3-GFP/cre)#Xzd mutation
(0 available)
Trpv1tm1Jul mutation
(1 available);
any
Trpv1 mutation
(59 available)
|
|
|
behavior/neurological
|
|
• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type
|
|
|
• mice have impaired nociceptive responses, showing increased latencies in tail-immersion and hot plate paradigms
|
integument
|
|
• robust itch behavior is observed after cheek injection of capsaicin compared to little hindpaw scratching seen in treated wild-type
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pirttm2Xzd mutation
(0 available);
any
Pirt mutation
(13 available)
Trpv1tm1Jul mutation
(1 available);
any
Trpv1 mutation
(59 available)
|
|
|
nervous system
|
|
• complete absence of Ca+2 signals in sensory neurons after capsaicin stimulation
|
Analysis Tools