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Targeted Allele Detail
Symbol: Trpv1tm1Jul
Name: transient receptor potential cation channel, subfamily V, member 1; targeted mutation 1, David Julius
MGI ID: MGI:1934023
Synonyms: Trpv-1-, TRPV1-KO, Vr1tm1Jul
Gene: Trpv1  Location: Chr11:73125118-73152068 bp, + strand  Genetic Position: Chr11, 45.25 cM, cytoband B3
Alliance: Trpv1tm1Jul page
Germline Transmission:  Earliest citation of germline transmission: J:61534
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by deleting an exon encoding part of the fifth and all of the sixth putative transmembrane domains of the channel, together with the intervening pore-loop region. Northern blot analysis showed that mRNA derived from dorsal root ganglia (DRG) of homozygous mice lacked detectable transcripts encoded by this allele. (J:61534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpv1 Mutation:  40 strains or lines available
Original:  J:61534 Caterina MJ, et al., Impaired nociception and pain sensation in mice lacking the capsaicin receptor [see comments]. Science. 2000 Apr 14;288(5464):306-13
All:  333 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory