Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Grid mutation
(1 available);
any
Lfng mutation
(32 available)
|
|
|
cardiovascular system
|
• at P4, significantly enhanced sprouting and increased vascular area is observed in the retina
|
vision/eye
|
• at P4, significantly enhanced sprouting and increased vascular area is observed in the retina
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Grid mutation
(1 available);
any
Lfng mutation
(32 available)
|
|
|
mortality/aging
|
• some neonatal lethality due to respiratory difficulties related to a malformed rib cage
• less severely affected mice survive
|
embryo
|
• defects in somite formation after E8.5
• size and shape are irregular
• metameric pattern is not maintained
|
skeleton
|
• number of ribs attached to the sternum is reduced
|
|
• some ribs are detached from the vertebral column
|
|
• regular metameric pattern of vertebrae is disrupted
|
|
• reduced number of cervical vertebrae
|
nervous system
reproductive system
|
• some, but not all, females are infertile
(J:48810)
• genetic background may contribute to whether or not mice are fertile
(J:105928)
|
hearing/vestibular/ear
N |
• at E18, homozygotes display no alterations in cochlear hair cell number or patterning relative to wild-type or heterozygous mice
|
hearing/vestibular/ear
|
• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
|
|
• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
|
|
• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes
|
nervous system
|
• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
|
|
• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
|
|
• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes
|
hearing/vestibular/ear
|
• at E18, these mutants display only partial suppression of the Jag2tm1Grid homozygous mutant phenotype in the IHC row
• in these mice, regions of two rows of IHCs are interspersed with regions of a single row of IHCs
|
nervous system
|
• at E18, these mutants display only partial suppression of the Jag2tm1Grid homozygous mutant phenotype in the IHC row
• in these mice, regions of two rows of IHCs are interspersed with regions of a single row of IHCs
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Grid mutation
(1 available);
any
Lfng mutation
(32 available)
Rfngtm1Grid mutation
(0 available);
any
Rfng mutation
(15 available)
|
|
|
skeleton
N |
• phenotypes of double homozygotes were identical to those of mice homozygous for Lfngtm1Grid only
|
|
• some ribs are detached from the vertebral column
|
|
• regular metameric pattern of vertebrae is disrupted
|