Phenotypes associated with this allele

• Allele Symbol: Xrcc1^tm1Rpe
• Allele Name: targeted mutation 1, Roger A Pedersen
• Allele ID: MGI:1932097
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xrcc1^tm1Rpe/Xrcc1^tm1Rpe	involves: 129X1/SvJ	MGI:2653517
cx2	Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc1^tm1Rpe/Xrcc1^tm1Rpe	involves: 129S2/SvPas * 129X1/SvJ	MGI:2653518

Genotype
MGI:2653517

hm1

• Allelic Composition: Xrcc1^tm1Rpe/Xrcc1^tm1Rpe
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:54226 )

• death by E8.5

• by E8.75, the egg cylinder was mostly resorbed

embryo

embryo phenotype ( J:54226 )

N • no evidence of extraembryonic tissue dysmorphology

N • no evidence of defective interaction between conceptus and the decidua

abnormal endoderm development ( J:54226 )

• at E6.5, embryonic endoderm morphology resembled that of visceral extraembryonic endoderm, consisting of large, columnar cells containing vacuoles, rather than the normal squamous cells

• at E7.5, the endoderm was crowded and formed occasional bulges

failure to gastrulate ( J:54226 )

• at E7.5, littermate controls had undergone gastrulation, while homozygous mutant mice had not

decreased embryo size ( J:54226 )

• evident by E7.5

absent mesoderm ( J:54226 )

• undetectable at E7.5

growth/size/body

decreased embryo size ( J:54226 )

• evident by E7.5

Genotype
MGI:2653518

cx2

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj; Xrcc1^tm1Rpe/Xrcc1^tm1Rpe
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

mortality/aging

embryonic lethality, complete penetrance ( J:54226 )

• death by E9.0 to E9.5, 12 to 24 hours after mice homozygous for Xpre1^tm1Rpe alone

embryo

embryonic growth arrest ( J:54226 )

• developmental arrest about 6 h after mice homozygous for Xpre1^tm1Rpe alone

• unlike mice homozygous for Xpre1^tm1Rpe alone, small amounts of mesoderm found

decreased embryo size ( J:54226 )

• but bigger than mice homozygous for Xpre1^tm1Rpe alone

growth/size/body

decreased embryo size ( J:54226 )

• but bigger than mice homozygous for Xpre1^tm1Rpe alone